1D Self-Assembly and Ice Recrystallization Inhibition Activity of Antifreeze Glycopeptide-Functionalized Perylene Bisimides

Madeleine K. Adam, Charles Jarrett-Wilkins, Michael Beards, Emiliyan Staykov, Liam R. MacFarlane, Toby D.M. Bell, Jacqueline M. Matthews, Ian Manners, Charl F.J. Faul, Pierre D.J. Moens, Robert N. Ben, Brendan L. Wilkinson*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)
260 Downloads (Pure)

Abstract

Antifreeze glycoproteins (AFGPs) are polymeric natural products that have drawn considerable interest in diverse research fields owing to their potent ice recrystallization inhibition (IRI) activity. Self-assembled materials have emerged as a promising class of biomimetic ice growth inhibitor, yet the development of AFGP-based supramolecular materials that emulate the aggregative behavior of AFGPs have not yet been reported. This work reports the first example of the 1D self-assembly and IRI activity of AFGP-functionalized perylene bisimides (AFGP-PBIs). Glycopeptide-functionalized PBIs underwent 1D self-assembly in water and showed modest IRI activity, which could be tuned through substitution of the PBI core. This work presents essential proof-of-principle for the development of novel IRIs as potential supramolecular cryoprotectants and glycoprotein mimics.

Original languageEnglish
Pages (from-to)7834-7839
Number of pages6
JournalChemistry - A European Journal
Volume24
Issue number31
Early online date12 Apr 2018
DOIs
Publication statusPublished - 4 Jun 2018

Structured keywords

  • BCS and TECS CDTs

Keywords

  • 1D self-assembly
  • antifreeze glycopeptides
  • perylene bisimides
  • pi interactions
  • soft matter

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