21st century excitatory amino acid research: A Q & A with Jeff Watkins and Dick Evans

Jeffrey C Watkins, Richard H Evans, Àlex Bayés, Sam Booker, Alasdair Gibb, Angela Mabb, Mark Mayer, Jack R Mellor, Elek Molnar, Li Niu, Arturo Ortega, Yuriy Pankratov, David Ramos-Vincente, Ada Rodríguez-Campuzano, Antonio Rodríguez-Moreno, Lu-Yang Wang, Lonnie Wollmuth, David Wyllie, Min Zhuo, Bruno Frenguelli

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

In 1981 Jeff Watkins and Dick Evans wrote what was to become a seminal review on excitatory amino acids (EAAs) and their receptors (Watkins and Evans, 1981). Bringing together various lines of evidence dating back over several decades on: the distribution in the nervous system of putative amino acid neurotransmitters; enzymes involved in their production and metabolism; the uptake and release of amino acids; binding of EAAs to membranes; the pharmacological action of endogenous excitatory amino acids and their synthetic analogues, and notably the actions of antagonists for the excitations caused by both nerve stimulation and exogenous agonists, often using pharmacological tools developed by Jeff and his colleagues, they provided a compelling account for EAAs, especially l-glutamate, as a bona fide neurotransmitter in the nervous system. The rest, as they say, is history, but far from being consigned to history, EAA research is in rude health well into the 21st Century as this series of Special Issues of Neuropharmacology exemplifies. With EAAs and their receptors flourishing across a wide range of disciplines and clinical conditions, we enter into a dialogue with two of the most prominent and influential figures in the early days of EAA research: Jeff Watkins and Dick Evans.
Original languageEnglish
Article number108743
Number of pages8
JournalNeuropharmacology
Volume198
Early online date5 Aug 2021
DOIs
Publication statusE-pub ahead of print - 5 Aug 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

  • glutamate receptor
  • pharmacology
  • drug discovery

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