7-8 Year Follow-up of the CoolCap Trial of Head Cooling for Neonatal Encephalopathy

R Guillet, AD Edwards, M Thoresen, DM Ferriero, PD Gluckman, A Whitelaw, AJ Gunn

Research output: Contribution to journalArticle (Academic Journal)peer-review

104 Citations (Scopus)

Abstract

Introduction:We sought to determine whether 18- to 22-mo neurodevelopmental outcomes predicted functional outcomes at 7-8 y for survivors of the CoolCap study of therapeutic hypothermia for neonates with hypoxic-ischemic encephalopathy.Results:WeeFIM ratings were completed at 7-8 y of age on 62 (32 cooled; 30 standard care) of 135 surviving children who had had neurodevelopmental assessment at 18 mo. There was 1 refusal, 58 lost to follow-up, and 14 children whose centers declined to participate. Disability status at 18 mo was strongly associated with WeeFIM ratings (P <0.001); there was no significant effect of treatment (P = 0.83).Discussion:Functional outcome at 7-8 y of survivors of neonatal encephalopathy is associated with 18-mo neurodevelopmental assessment, supporting the long-term predictive value of a favorable outcome at 18 mo assessed by published trials of therapeutic hypothermia.Methods:All surviving children who participated in the CoolCap study and were assessed at 18 mo were eligible for reassessment using the WeeFIM instrument that qualitatively measures self-care, mobility, and cognitive function. Center investigators obtained consent from the families for a certified researcher to administer the WeeFIM instrument by phone.
Translated title of the contribution7-8 Year Follow-up of the CoolCap Trial of Head Cooling for Neonatal Encephalopathy
Original languageEnglish
Pages (from-to)205 - 209
Number of pages5
JournalPediatric Research
Volume71(2)
DOIs
Publication statusPublished - Feb 2012

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