75 years of opioid research: the exciting but vain quest for the Holy Grail

AD Corbett, G Henderson, AT McKnight, SJ Patterson

Research output: Contribution to journalArticle (Academic Journal)peer-review

215 Citations (Scopus)

Abstract

Over the 75-year lifetime of the British Pharmacological Society there has been an enormous expansion in our understanding of how opioid drugs act on the nervous system, with much of this effort aimed at developing powerful analgesic drugs devoid of the side effects associated with morphine – the Holy Grail of opioid research. At the molecular and cellular level multiple opioid receptors have been cloned and characterised, their potential for oligomerisation determined, a large family of endogenous opioid agonists has been discovered, multiple second messengers identified and our understanding of the adaptive changes to prolonged exposure to opioid drugs (tolerance and physical dependence) enhanced. In addition, we now have greater understanding of the processes by which opioids produce the euphoria that gives rise to the intense craving for these drugs in opioid addicts. In this article, we review the historical pathway of opioid research that has led to our current state of knowledge.
Translated title of the contribution75 years of opioid research: the exciting but vain quest for the Holy Grail
Original languageEnglish
Pages (from-to)S153 - S162
Number of pages10
JournalBritish Journal of Pharmacology
Volume147 (Suppl 1)
DOIs
Publication statusPublished - Jan 2006

Bibliographical note

Publisher: Nature Publishing Group

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