A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia

Christopher J Peters, Jonathan R E Rees, Richard H Hardwick, James S Hardwick, Sarah L Vowler, Chin-Ann J Ong, Chunsheng Zhang, Vicki Save, Maria O'Donovan, Doris Rassl, Derek Alderson, Carlos Caldas, Rebecca C Fitzgerald, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group

Research output: Contribution to journalArticle (Academic Journal)

101 Citations (Scopus)

Abstract

The incidence of esophageal and junctional adenocarcinoma has increased 6-fold in the past 30 years and 5-year survival remains approximately 20%. Current staging is limited in its ability to predict survival which has ramifications for treatment choices. The aim of this study was to generate and validate a molecular prognostic signature for esophageal adenocarcinoma.
Original languageEnglish
Pages (from-to)1995-2004.e15
JournalGastroenterology
Volume139
Issue number6
DOIs
Publication statusPublished - 2010

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