A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia

Christopher J Peters; Jonathan R E Rees; Richard H Hardwick; James S Hardwick; Sarah L Vowler; Chin-Ann J Ong; Chunsheng Zhang; Vicki Save; Maria O'Donovan; Doris Rassl; Derek Alderson; Carlos Caldas; Rebecca C Fitzgerald; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group

doi:10.1053/j.gastro.2010.05.080

A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia

Christopher J Peters, Jonathan R E Rees, Richard H Hardwick, James S Hardwick, Sarah L Vowler, Chin-Ann J Ong, Chunsheng Zhang, Vicki Save, Maria O'Donovan, Doris Rassl, Derek Alderson, Carlos Caldas, Rebecca C Fitzgerald, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

The incidence of esophageal and junctional adenocarcinoma has increased 6-fold in the past 30 years and 5-year survival remains approximately 20%. Current staging is limited in its ability to predict survival which has ramifications for treatment choices. The aim of this study was to generate and validate a molecular prognostic signature for esophageal adenocarcinoma.

Original language	English
Pages (from-to)	1995-2004.e15
Journal	Gastroenterology
Volume	139
Issue number	6
DOIs	https://doi.org/10.1053/j.gastro.2010.05.080
Publication status	Published - 2010

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http://www.gastrojournal.org/article/S0016-5085(10)00842-5/abstract

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Peters, C. J., Rees, J. R. E., Hardwick, R. H., Hardwick, J. S., Vowler, S. L., Ong, C-A. J., Zhang, C., Save, V., O'Donovan, M., Rassl, D., Alderson, D., Caldas, C., Fitzgerald, R. C., & Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group (2010). A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia. Gastroenterology, 139(6), 1995-2004.e15. https://doi.org/10.1053/j.gastro.2010.05.080

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title = "A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia",

abstract = "The incidence of esophageal and junctional adenocarcinoma has increased 6-fold in the past 30 years and 5-year survival remains approximately 20%. Current staging is limited in its ability to predict survival which has ramifications for treatment choices. The aim of this study was to generate and validate a molecular prognostic signature for esophageal adenocarcinoma.",

author = "Peters, {Christopher J} and Rees, {Jonathan R E} and Hardwick, {Richard H} and Hardwick, {James S} and Vowler, {Sarah L} and Ong, {Chin-Ann J} and Chunsheng Zhang and Vicki Save and Maria O'Donovan and Doris Rassl and Derek Alderson and Carlos Caldas and Fitzgerald, {Rebecca C} and {Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group}",

year = "2010",

doi = "10.1053/j.gastro.2010.05.080",

language = "English",

volume = "139",

pages = "1995--2004.e15",

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Peters, CJ, Rees, JRE, Hardwick, RH, Hardwick, JS, Vowler, SL, Ong, C-AJ, Zhang, C, Save, V, O'Donovan, M, Rassl, D, Alderson, D, Caldas, C, Fitzgerald, RC & Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group 2010, 'A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia', Gastroenterology, vol. 139, no. 6, pp. 1995-2004.e15. https://doi.org/10.1053/j.gastro.2010.05.080

TY - JOUR

T1 - A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia

AU - Peters, Christopher J

AU - Rees, Jonathan R E

AU - Hardwick, Richard H

AU - Hardwick, James S

AU - Vowler, Sarah L

AU - Ong, Chin-Ann J

AU - Zhang, Chunsheng

AU - Save, Vicki

AU - O'Donovan, Maria

AU - Rassl, Doris

AU - Alderson, Derek

AU - Caldas, Carlos

AU - Fitzgerald, Rebecca C

AU - Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group

PY - 2010

Y1 - 2010

N2 - The incidence of esophageal and junctional adenocarcinoma has increased 6-fold in the past 30 years and 5-year survival remains approximately 20%. Current staging is limited in its ability to predict survival which has ramifications for treatment choices. The aim of this study was to generate and validate a molecular prognostic signature for esophageal adenocarcinoma.

AB - The incidence of esophageal and junctional adenocarcinoma has increased 6-fold in the past 30 years and 5-year survival remains approximately 20%. Current staging is limited in its ability to predict survival which has ramifications for treatment choices. The aim of this study was to generate and validate a molecular prognostic signature for esophageal adenocarcinoma.

U2 - 10.1053/j.gastro.2010.05.080

DO - 10.1053/j.gastro.2010.05.080

M3 - Article (Academic Journal)

C2 - 20621683

VL - 139

SP - 1995-2004.e15

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 6

ER -

A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia

Abstract

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