A biomimetic receptor for glucose

Robert A. Tromans, Tom S. Carter, Laurent Chabanne, Matthew P. Crump, Hongyu Li, Johnathan V. Matlock, Michael G. Orchard, Anthony P. Davis*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)
225 Downloads (Pure)

Abstract

Specific molecular recognition is routine for biology, but has proved difficult to achieve in synthetic systems. Carbohydrate substrates are especially challenging, because of their diversity and similarity to water, the biological solvent. Here we report a synthetic receptor for glucose, which is biomimetic in both design and capabilities. The core structure is simple and symmetrical, yet provides a cavity which almost perfectly complements the all-equatorial β-pyranoside substrate. The receptor’s affinity for glucose, at Ka ~ 18,000 M−1, compares well with natural receptor systems. Selectivities also reach biological levels. Most other saccharides are bound approximately 100 times more weakly, while non-carbohydrate substrates are ignored. Glucose-binding molecules are required for initiatives in diabetes treatment, such as continuous glucose monitoring and glucose-responsive insulin. The performance and tunability of this system augur well for such applications.
Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalNature Chemistry
Volume11
Issue number1
Early online date12 Nov 2018
DOIs
Publication statusPublished - Jan 2019

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Structured keywords

  • Bristol BioDesign Institute
  • BCS and TECS CDTs

Keywords

  • SYNTHETIC BIOLOGY

Cite this

Tromans, R. A., Carter, T. S., Chabanne, L., Crump, M. P., Li, H., Matlock, J. V., Orchard, M. G., & Davis, A. P. (2019). A biomimetic receptor for glucose. Nature Chemistry, 11(1), 52-56. https://doi.org/10.1038/s41557-018-0155-z