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A biomimetic receptor for glucose

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalNature Chemistry
Volume11
Issue number1
Early online date12 Nov 2018
DOIs
DateAccepted/In press - 5 Sep 2018
DateE-pub ahead of print - 12 Nov 2018
DatePublished (current) - Jan 2019

Abstract

Specific molecular recognition is routine for biology, but has proved difficult to achieve in synthetic systems. Carbohydrate substrates are especially challenging, because of their diversity and similarity to water, the biological solvent. Here we report a synthetic receptor for glucose, which is biomimetic in both design and capabilities. The core structure is simple and symmetrical, yet provides a cavity which almost perfectly complements the all-equatorial β-pyranoside substrate. The receptor’s affinity for glucose, at Ka ~ 18,000 M−1, compares well with natural receptor systems. Selectivities also reach biological levels. Most other saccharides are bound approximately 100 times more weakly, while non-carbohydrate substrates are ignored. Glucose-binding molecules are required for initiatives in diabetes treatment, such as continuous glucose monitoring and glucose-responsive insulin. The performance and tunability of this system augur well for such applications.

    Structured keywords

  • Bristol BioDesign Institute

    Research areas

  • SYNTHETIC BIOLOGY

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  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Nature at DOI: 10.1038/s41557-018-0155-z. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 1023 KB, PDF document

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