A blueprint for translational regenerative medicine

James P.K. Armstrong; Timothy J. Keane; Anne C. Roques; P. Stephen Patrick; Claire M. Mooney; Wei Li Kuan; Venkat Pisupati; Richard O.C. Oreffo; Daniel J. Stuckey; Fiona M. Watt; Stuart J. Forbes; Roger A. Barker; Molly M. Stevens

doi:10.1126/scitranslmed.aaz2253

A blueprint for translational regenerative medicine

James P.K. Armstrong^*, Timothy J. Keane, Anne C. Roques, P. Stephen Patrick, Claire M. Mooney, Wei Li Kuan, Venkat Pisupati, Richard O.C. Oreffo, Daniel J. Stuckey, Fiona M. Watt, Stuart J. Forbes, Roger A. Barker, Molly M. Stevens

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

22 Citations (Scopus)

Abstract

The past few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions to the so-called “valley of death.” Here, we present a proposed blueprint for translational regenerative medicine. We offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development. Last, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine.

Original language	English
Article number	eaaz2253
Journal	Science Translational Medicine
Volume	12
Issue number	572
DOIs	https://doi.org/10.1126/scitranslmed.aaz2253 https://doi.org/10.1126/SCITRANSLMED.AAZ2253
Publication status	Published - 2 Dec 2020

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

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Armstrong, J. P. K., Keane, T. J., Roques, A. C., Patrick, P. S., Mooney, C. M., Kuan, W. L., Pisupati, V., Oreffo, R. O. C., Stuckey, D. J., Watt, F. M., Forbes, S. J., Barker, R. A., & Stevens, M. M. (2020). A blueprint for translational regenerative medicine. Science Translational Medicine, 12(572), Article eaaz2253. https://doi.org/10.1126/scitranslmed.aaz2253, https://doi.org/10.1126/SCITRANSLMED.AAZ2253

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title = "A blueprint for translational regenerative medicine",

abstract = "The past few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions to the so-called “valley of death.” Here, we present a proposed blueprint for translational regenerative medicine. We offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development. Last, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine.",

author = "Armstrong, {James P.K.} and Keane, {Timothy J.} and Roques, {Anne C.} and Patrick, {P. Stephen} and Mooney, {Claire M.} and Kuan, {Wei Li} and Venkat Pisupati and Oreffo, {Richard O.C.} and Stuckey, {Daniel J.} and Watt, {Fiona M.} and Forbes, {Stuart J.} and Barker, {Roger A.} and Stevens, {Molly M.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works",

year = "2020",

month = dec,

day = "2",

doi = "10.1126/scitranslmed.aaz2253",

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Armstrong, JPK, Keane, TJ, Roques, AC, Patrick, PS, Mooney, CM, Kuan, WL, Pisupati, V, Oreffo, ROC, Stuckey, DJ, Watt, FM, Forbes, SJ, Barker, RA & Stevens, MM 2020, 'A blueprint for translational regenerative medicine', Science Translational Medicine, vol. 12, no. 572, eaaz2253. https://doi.org/10.1126/scitranslmed.aaz2253, https://doi.org/10.1126/SCITRANSLMED.AAZ2253

TY - JOUR

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AU - Armstrong, James P.K.

AU - Keane, Timothy J.

AU - Roques, Anne C.

AU - Patrick, P. Stephen

AU - Mooney, Claire M.

AU - Kuan, Wei Li

AU - Pisupati, Venkat

AU - Oreffo, Richard O.C.

AU - Stuckey, Daniel J.

AU - Watt, Fiona M.

AU - Forbes, Stuart J.

AU - Barker, Roger A.

AU - Stevens, Molly M.

PY - 2020/12/2

Y1 - 2020/12/2

N2 - The past few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions to the so-called “valley of death.” Here, we present a proposed blueprint for translational regenerative medicine. We offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development. Last, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine.

AB - The past few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions to the so-called “valley of death.” Here, we present a proposed blueprint for translational regenerative medicine. We offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development. Last, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine.

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DO - 10.1126/scitranslmed.aaz2253

M3 - Review article (Academic Journal)

C2 - 33268507

SN - 1946-6234

VL - 12

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 572

M1 - eaaz2253

ER -

A blueprint for translational regenerative medicine

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