A brief tour of epidemiologic epigenetics and mental health

Charleen D. Adams

Research output: Contribution to journalReview article (Academic Journal)peer-review

2 Citations (Scopus)


The epidemiologic study of DNA methylation (DNAm) and mental health is a burgeoning area, but confounding and reverse causation remain important to know about. Whether use of non-brain tissues is appropriate when investigating brain phenotypes depends on the hypothesis and whether the goal is causality or to identify biomarkers. Look-ups of the correspondence between DNAm in blood and brain and use of Mendelian randomization (MR) can be done to follow-up, to some degree, on the causal nature of some findings. Social scientists, health methodologists (epidemiologists), and basic scientists — thinkers who view epigenetics and mental health from different perspectives — can come together in the design and framing of findings to avoid pitfalls and innovate beyond what each could do alone.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalCurrent Opinion in Psychology
Early online date9 Aug 2018
Publication statusPublished - 1 Jun 2019


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