A broader view of dementia: Multiple co-pathologies are the norm

Elizabeth J. Coulthard*, Seth Love

*Corresponding author for this work

Research output: Contribution to journalComment/debate (Academic Journal)

5 Citations (Scopus)
120 Downloads (Pure)

Abstract

Alzheimer’s disease and other dementias are defined by hallmark protein abnormalities found in brain tissue post mortem. Despite increasingly accurate diagnosis of primary pathology in life, treatments targeting the underlying protein abnormalities in Alzheimer’s disease have so far not worked. Why is dementia proving so hard to treat? One argument is that treatments are given too late in the course of illness – by the time of diagnosis, disease has progressed for a decade or more, has initiated self-perpetuating secondary processes and is no longer modifiable. A related, but distinct argument is presented in this issue by Robinson and co-workers, who demonstrate concurrence of multiple different abnormal proteins in dementias such as Alzheimer’s disease, hinting at the likelihood that treatment might require a multi-pronged approach (REF – Robinson et al).
Original languageEnglish
Article numberawy153
Pages (from-to)1894-1897
Number of pages4
JournalBrain
Volume141
Issue number7
Early online date27 Jun 2018
DOIs
Publication statusPublished - Jul 2018

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