A case of chronic asymptomatic central pontine myelinolysis with histological evidence of remyelination

Harry R Haynes, Andrea Cordaro*, Marcus Likeman, Seth Love

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)
240 Downloads (Pure)

Abstract

Central pontine myelinolysis (CPM) is a neurological demyelinating disease of the pons. Although usually associated with rapid correction of hyponatremia, CPM may occur despite normonatremia, is often associated with chronic alcoholism and may be asymptomatic. Histological confirmation of asymptomatic CPM is rare. We describe an unusual post-mortem case of extensive but asymptomatic CPM in a chronic alcoholic patient with normonatremia. The affected part of the pons contained thinly myelinated axons with appearances supporting remyelination. We suggest that remyelination may account for the subclinical nature of this patient's CPM.

Original languageEnglish
Number of pages3
JournalForensic Science, Medicine, and Pathology
Early online date25 Nov 2017
DOIs
Publication statusE-pub ahead of print - 25 Nov 2017

Keywords

  • Alcohol
  • Asymptomatic
  • Central pontine myelinolysis
  • Post-mortem
  • Remyelination

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