A case of placental insufficiency and premature delivery in a Fontan pregnancy: physiological insights and considerations on risk stratification

Maria Victoria  Ordonez; Giovanni Biglino; Massimo Caputo; Brenda Kelly; Aarthi R. Mohan; Johanna Trinder; Stephanie L Curtis

A case of placental insufficiency and premature delivery in a Fontan pregnancy: physiological insights and considerations on risk stratification

Maria Victoria Ordonez ^*, Giovanni Biglino, Massimo Caputo, Brenda Kelly, Aarthi R. Mohan, Johanna Trinder, Stephanie L Curtis

^*Corresponding author for this work

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

Objectives: The coexistence of two complex physiologies such as Fontan and pregnancy is still not fully understood. We aim to add a unique and essential knowledge to help our colleagues in the management of Fontan patients that undergo pregnancy as well as the foetus and the placenta perfusion.

Methods and Results: We analyse the coexistence of Fontan and pregnancy physiology on a complex case of a woman with hypoplastic left heart syndrome (HLHS) palliated with a univentricular repair who became pregnant, delivered very prematurely and had atypical placental findings.

Conclusion: Histopathological analysis of the placenta could help us to refine the understanding of Fontan physiology adaptation during pregnancy, predict women and foetal outcomes as well as to plan a better pre-pregnancy status. However, further evidence is needed in order to reach a more solid and unify conclusion.

Original language	English
Journal	Open Heart
Publication status	Accepted/In press - 2 Oct 2020

Structured keywords

Bristol Heart Institute

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title = "A case of placental insufficiency and premature delivery in a Fontan pregnancy: physiological insights and considerations on risk stratification",

abstract = "Objectives: The coexistence of two complex physiologies such as Fontan and pregnancy is still not fully understood. We aim to add a unique and essential knowledge to help our colleagues in the management of Fontan patients that undergo pregnancy as well as the foetus and the placenta perfusion. Methods and Results: We analyse the coexistence of Fontan and pregnancy physiology on a complex case of a woman with hypoplastic left heart syndrome (HLHS) palliated with a univentricular repair who became pregnant, delivered very prematurely and had atypical placental findings.Conclusion: Histopathological analysis of the placenta could help us to refine the understanding of Fontan physiology adaptation during pregnancy, predict women and foetal outcomes as well as to plan a better pre-pregnancy status. However, further evidence is needed in order to reach a more solid and unify conclusion.",

author = "Ordonez, {Maria Victoria} and Giovanni Biglino and Massimo Caputo and Brenda Kelly and Mohan, {Aarthi R.} and Johanna Trinder and Curtis, {Stephanie L}",

year = "2020",

month = oct,

day = "2",

language = "English",

journal = "Open Heart",

issn = "2053-3624",

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A case of placental insufficiency and premature delivery in a Fontan pregnancy : physiological insights and considerations on risk stratification. / Ordonez , Maria Victoria ; Biglino, Giovanni ; Caputo, Massimo; Kelly, Brenda; Mohan, Aarthi R.; Trinder, Johanna; Curtis, Stephanie L.

In: Open Heart, 02.10.2020.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - A case of placental insufficiency and premature delivery in a Fontan pregnancy

T2 - physiological insights and considerations on risk stratification

AU - Ordonez , Maria Victoria

AU - Biglino, Giovanni

AU - Caputo, Massimo

AU - Kelly, Brenda

AU - Mohan, Aarthi R.

AU - Trinder, Johanna

AU - Curtis, Stephanie L

PY - 2020/10/2

Y1 - 2020/10/2

N2 - Objectives: The coexistence of two complex physiologies such as Fontan and pregnancy is still not fully understood. We aim to add a unique and essential knowledge to help our colleagues in the management of Fontan patients that undergo pregnancy as well as the foetus and the placenta perfusion. Methods and Results: We analyse the coexistence of Fontan and pregnancy physiology on a complex case of a woman with hypoplastic left heart syndrome (HLHS) palliated with a univentricular repair who became pregnant, delivered very prematurely and had atypical placental findings.Conclusion: Histopathological analysis of the placenta could help us to refine the understanding of Fontan physiology adaptation during pregnancy, predict women and foetal outcomes as well as to plan a better pre-pregnancy status. However, further evidence is needed in order to reach a more solid and unify conclusion.

AB - Objectives: The coexistence of two complex physiologies such as Fontan and pregnancy is still not fully understood. We aim to add a unique and essential knowledge to help our colleagues in the management of Fontan patients that undergo pregnancy as well as the foetus and the placenta perfusion. Methods and Results: We analyse the coexistence of Fontan and pregnancy physiology on a complex case of a woman with hypoplastic left heart syndrome (HLHS) palliated with a univentricular repair who became pregnant, delivered very prematurely and had atypical placental findings.Conclusion: Histopathological analysis of the placenta could help us to refine the understanding of Fontan physiology adaptation during pregnancy, predict women and foetal outcomes as well as to plan a better pre-pregnancy status. However, further evidence is needed in order to reach a more solid and unify conclusion.

M3 - Article (Academic Journal)

JO - Open Heart

JF - Open Heart

SN - 2053-3624

ER -