A closed-circuit neonatal xenon delivery system: technical neuroprotection feasibility study in newborn pigs

E Chakkarapani, M Thoresen, CE Hobbs, K Aquilina, X Liu, J Dingley

Research output: Contribution to journalArticle (Academic Journal)peer-review

40 Citations (Scopus)

Abstract

Asphyxia accounts for 23% of the 4 million annual global neonatal deaths. In developed countries, the incidence of death or severe disability after hypoxic-ischemic (HI) encephalopathy is 1–2/1000 infants born at term. Hypothermia (HT) benefits newborns post-HI and is rapidly entering clinical use. Xenon (Xe), a scarce and expensive anesthetic, combined with HT markedly increases neuroprotection in small animal HI models. The low-Xe uptake of the patient favors the use of closed-circuit breathing system for efficiency and economy. We developed a system for delivering Xe to mechanically ventilated neonates, then investigated its technical and practical feasibility in a previously described neonatal pig model approximating the clinical scenario of global HI injury, prolonged Xe delivery with and without HT as a potential therapy, subsequent neonatal intensive care unit management, and tracheal extubation.
Translated title of the contributionA closed-circuit neonatal xenon delivery system: technical neuroprotection feasibility study in newborn pigs
Original languageEnglish
Pages (from-to)451 - 460
Number of pages10
JournalAnesthesia and Analgesia
Volume109
Issue number2
DOIs
Publication statusPublished - 2 Aug 2009

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