A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Timothy M Frayling, Nicholas J Timpson, Michael N Weedon, Eleftheria Zeggini, Rachel M Freathy, Cecilia M Lindgren, John R B Perry, Katherine S Elliott, Hana Lango, Nigel W Rayner, Beverley Shields, Lorna W Harries, Jeffrey C Barrett, Sian Ellard, Christopher J Groves, Bridget Knight, Ann-Marie Patch, Andy R Ness, Shah Ebrahim, Debbie A LawlorSusan M Ring, Yoav Ben-Shlomo, Marjo-Riitta Jarvelin, Ulla Sovio, Amanda J Bennett, David Melzer, Luigi Ferrucci, Ruth J F Loos, Inês Barroso, Nicholas J Wareham, Fredrik Karpe, Katharine R Owen, Lon R Cardon, Mark Walker, Graham A Hitman, Colin N A Palmer, Alex S F Doney, Andrew D Morris, George Davey Smith, Andrew T Hattersley, Mark I McCarthy

Research output: Contribution to journalArticle (Academic Journal)peer-review

2903 Citations (Scopus)

Abstract

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.
Original languageEnglish
Pages (from-to)889-94
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume316
Issue number5826
DOIs
Publication statusPublished - Apr 2007

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