A comparison of two brief screening measures of cognitive impairment in Huntington's disease

Laura Mickes, Mark Jacobson, Guerry Peavy, John T Wixted, Stephanie Lessig, Jody L Goldstein, Jody Corey-Bloom

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

The goal of this study was to explore whether the Montreal Cognitive Assessment (MoCA), a new screening instrument, would be more sensitive to mild to moderate cognitive impairment in Huntington's disease (HD) than an established screening measure, the Mini Mental State Exam (MMSE). Our reasoning for this query is that the MoCA includes a broader range of test items and an additional assessment of executive functioning and attention compared with the MMSE. Using the receiver operating characteristic (ROC) analysis to examine performance of HD and control groups on both tests on overall scores and scores from various subdomains (i.e., visuospatial abilities) revealed that the MoCA achieved higher sensitivity without sacrificing specificity in many domains relative to the MMSE.

Original languageEnglish
Pages (from-to)2229-33
Number of pages5
JournalMovement Disorders
Volume25
Issue number13
DOIs
Publication statusPublished - 15 Oct 2010

Structured keywords

  • Cognitive Science

Keywords

  • Adult
  • Area Under Curve
  • Cognition Disorders/diagnosis
  • Executive Function/physiology
  • Female
  • Humans
  • Huntington Disease/complications
  • Male
  • Mental Status Schedule
  • Middle Aged
  • Neuropsychological Tests
  • ROC Curve

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