A comparison of two brief screening measures of cognitive impairment in Huntington's disease

Laura Mickes; Mark Jacobson; Guerry Peavy; John T Wixted; Stephanie Lessig; Jody L Goldstein; Jody Corey-Bloom

doi:10.1002/mds.23181

A comparison of two brief screening measures of cognitive impairment in Huntington's disease

Laura Mickes, Mark Jacobson, Guerry Peavy, John T Wixted, Stephanie Lessig, Jody L Goldstein, Jody Corey-Bloom

Research output: Contribution to journal › Article (Academic Journal) › peer-review

39 Citations (Scopus)

Abstract

The goal of this study was to explore whether the Montreal Cognitive Assessment (MoCA), a new screening instrument, would be more sensitive to mild to moderate cognitive impairment in Huntington's disease (HD) than an established screening measure, the Mini Mental State Exam (MMSE). Our reasoning for this query is that the MoCA includes a broader range of test items and an additional assessment of executive functioning and attention compared with the MMSE. Using the receiver operating characteristic (ROC) analysis to examine performance of HD and control groups on both tests on overall scores and scores from various subdomains (i.e., visuospatial abilities) revealed that the MoCA achieved higher sensitivity without sacrificing specificity in many domains relative to the MMSE.

Original language	English
Pages (from-to)	2229-33
Number of pages	5
Journal	Movement Disorders
Volume	25
Issue number	13
DOIs	https://doi.org/10.1002/mds.23181
Publication status	Published - 15 Oct 2010

Structured keywords

Cognitive Science

Keywords

Adult
Area Under Curve
Cognition Disorders/diagnosis
Executive Function/physiology
Female
Humans
Huntington Disease/complications
Male
Mental Status Schedule
Middle Aged
Neuropsychological Tests
ROC Curve

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title = "A comparison of two brief screening measures of cognitive impairment in Huntington's disease",

abstract = "The goal of this study was to explore whether the Montreal Cognitive Assessment (MoCA), a new screening instrument, would be more sensitive to mild to moderate cognitive impairment in Huntington's disease (HD) than an established screening measure, the Mini Mental State Exam (MMSE). Our reasoning for this query is that the MoCA includes a broader range of test items and an additional assessment of executive functioning and attention compared with the MMSE. Using the receiver operating characteristic (ROC) analysis to examine performance of HD and control groups on both tests on overall scores and scores from various subdomains (i.e., visuospatial abilities) revealed that the MoCA achieved higher sensitivity without sacrificing specificity in many domains relative to the MMSE.",

keywords = "Adult, Area Under Curve, Cognition Disorders/diagnosis, Executive Function/physiology, Female, Humans, Huntington Disease/complications, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, ROC Curve",

author = "Laura Mickes and Mark Jacobson and Guerry Peavy and Wixted, {John T} and Stephanie Lessig and Goldstein, {Jody L} and Jody Corey-Bloom",

year = "2010",

month = oct,

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doi = "10.1002/mds.23181",

language = "English",

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AU - Mickes, Laura

AU - Jacobson, Mark

AU - Peavy, Guerry

AU - Wixted, John T

AU - Lessig, Stephanie

AU - Goldstein, Jody L

AU - Corey-Bloom, Jody

PY - 2010/10/15

Y1 - 2010/10/15

N2 - The goal of this study was to explore whether the Montreal Cognitive Assessment (MoCA), a new screening instrument, would be more sensitive to mild to moderate cognitive impairment in Huntington's disease (HD) than an established screening measure, the Mini Mental State Exam (MMSE). Our reasoning for this query is that the MoCA includes a broader range of test items and an additional assessment of executive functioning and attention compared with the MMSE. Using the receiver operating characteristic (ROC) analysis to examine performance of HD and control groups on both tests on overall scores and scores from various subdomains (i.e., visuospatial abilities) revealed that the MoCA achieved higher sensitivity without sacrificing specificity in many domains relative to the MMSE.

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KW - Adult

KW - Area Under Curve

KW - Cognition Disorders/diagnosis

KW - Executive Function/physiology

KW - Female

KW - Humans

KW - Huntington Disease/complications

KW - Male

KW - Mental Status Schedule

KW - Middle Aged

KW - Neuropsychological Tests

KW - ROC Curve

U2 - 10.1002/mds.23181

DO - 10.1002/mds.23181

M3 - Article (Academic Journal)

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JO - Movement Disorders

JF - Movement Disorders

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ER -

A comparison of two brief screening measures of cognitive impairment in Huntington's disease

Abstract

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Keywords

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