A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample

Ma'en Obeidat; Louise V Wain; Nick Shrine; Noor Kalsheker; Maria Soler Artigas; Emmanouela Repapi; Paul R Burton; Toby Johnson; Adaikalavan Ramasamy; Jing Hua Zhao; Guangju Zhai; Jennifer E Huffman; Veronique Vitart; Eva Albrecht; Wilmar Igl; Anna-Liisa Hartikainen; Anneli Pouta; Gemma Cadby; Jennie Hui; Lyle J Palmer; David Hadley; Wendy L McArdle; Alicja R Rudnicka; Inês Barroso; Ruth J F Loos; Nicholas J Wareham; Massimo Mangino; Nicole Soranzo; Tim D Spector; Sven Gläser; Georg Homuth; Henry Völzke; Panos Deloukas; Raquel Granell; John Henderson; Ivica Grkovic; Stipan Jankovic; Lina Zgaga; Ozren Polašek; Igor Rudan; Alan F Wright; Harry Campbell; Sarah H Wild; James F Wilson; Joachim Heinrich; Medea Imboden; Nicole M Probst-Hensch; Ulf Gyllensten; Åsa Johansson; Ghazal Zaboli; SpiroMeta Consortium

doi:10.1371/journal.pone.0019382

A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample

Ma'en Obeidat, Louise V Wain, Nick Shrine, Noor Kalsheker, Maria Soler Artigas, Emmanouela Repapi, Paul R Burton, Toby Johnson, Adaikalavan Ramasamy, Jing Hua Zhao, Guangju Zhai, Jennifer E Huffman, Veronique Vitart, Eva Albrecht, Wilmar Igl, Anna-Liisa Hartikainen, Anneli Pouta, Gemma Cadby, Jennie Hui, Lyle J PalmerDavid Hadley, Wendy L McArdle, Alicja R Rudnicka, Inês Barroso, Ruth J F Loos, Nicholas J Wareham, Massimo Mangino, Nicole Soranzo, Tim D Spector, Sven Gläser, Georg Homuth, Henry Völzke, Panos Deloukas, Raquel Granell, John Henderson, Ivica Grkovic, Stipan Jankovic, Lina Zgaga, Ozren Polašek, Igor Rudan, Alan F Wright, Harry Campbell, Sarah H Wild, James F Wilson, Joachim Heinrich, Medea Imboden, Nicole M Probst-Hensch, Ulf Gyllensten, Åsa Johansson, Ghazal Zaboli, SpiroMeta Consortium

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

50 Citations (Scopus)

Abstract

Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium).

Original language	English
Pages (from-to)	e19382
Journal	PLOS ONE
Volume	6
Issue number	5
DOIs	https://doi.org/10.1371/journal.pone.0019382
Publication status	Published - 2011

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THE NATURAL HISTORY OF ASTHMA AND WHEEZING ILLNESSES FROM BIRTH TO ADOLESCENCE: DETERMINANTS OF THE REMISSION OF ASTHMA
Henderson, A. J. W. (Principal Investigator)
1/10/06 → 1/10/10
Project: Research

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Obeidat, M., Wain, L. V., Shrine, N., Kalsheker, N., Soler Artigas, M., Repapi, E., Burton, P. R., Johnson, T., Ramasamy, A., Zhao, J. H., Zhai, G., Huffman, J. E., Vitart, V., Albrecht, E., Igl, W., Hartikainen, A.-L., Pouta, A., Cadby, G., Hui, J., ... SpiroMeta Consortium (2011). A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample. PLOS ONE, 6(5), e19382. https://doi.org/10.1371/journal.pone.0019382

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title = "A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample",

abstract = "Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium).",

author = "Ma'en Obeidat and Wain, \{Louise V\} and Nick Shrine and Noor Kalsheker and \{Soler Artigas\}, Maria and Emmanouela Repapi and Burton, \{Paul R\} and Toby Johnson and Adaikalavan Ramasamy and Zhao, \{Jing Hua\} and Guangju Zhai and Huffman, \{Jennifer E\} and Veronique Vitart and Eva Albrecht and Wilmar Igl and Anna-Liisa Hartikainen and Anneli Pouta and Gemma Cadby and Jennie Hui and Palmer, \{Lyle J\} and David Hadley and McArdle, \{Wendy L\} and Rudnicka, \{Alicja R\} and In{\^e}s Barroso and Loos, \{Ruth J F\} and Wareham, \{Nicholas J\} and Massimo Mangino and Nicole Soranzo and Spector, \{Tim D\} and Sven Gl{\"a}ser and Georg Homuth and Henry V{\"o}lzke and Panos Deloukas and Raquel Granell and John Henderson and Ivica Grkovic and Stipan Jankovic and Lina Zgaga and Ozren Pola{\v s}ek and Igor Rudan and Wright, \{Alan F\} and Harry Campbell and Wild, \{Sarah H\} and Wilson, \{James F\} and Joachim Heinrich and Medea Imboden and Probst-Hensch, \{Nicole M\} and Ulf Gyllensten and {\AA}sa Johansson and Ghazal Zaboli and \{SpiroMeta Consortium\}",

year = "2011",

doi = "10.1371/journal.pone.0019382",

language = "English",

volume = "6",

pages = "e19382",

journal = "PLOS ONE",

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Obeidat, M, Wain, LV, Shrine, N, Kalsheker, N, Soler Artigas, M, Repapi, E, Burton, PR, Johnson, T, Ramasamy, A, Zhao, JH, Zhai, G, Huffman, JE, Vitart, V, Albrecht, E, Igl, W, Hartikainen, A-L, Pouta, A, Cadby, G, Hui, J, Palmer, LJ, Hadley, D, McArdle, WL, Rudnicka, AR, Barroso, I, Loos, RJF, Wareham, NJ, Mangino, M, Soranzo, N, Spector, TD, Gläser, S, Homuth, G, Völzke, H, Deloukas, P, Granell, R, Henderson, J, Grkovic, I, Jankovic, S, Zgaga, L, Polašek, O, Rudan, I, Wright, AF, Campbell, H, Wild, SH, Wilson, JF, Heinrich, J, Imboden, M, Probst-Hensch, NM, Gyllensten, U, Johansson, Å, Zaboli, G & SpiroMeta Consortium 2011, 'A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample', PLOS ONE, vol. 6, no. 5, pp. e19382. https://doi.org/10.1371/journal.pone.0019382

TY - JOUR

T1 - A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample

AU - Obeidat, Ma'en

AU - Wain, Louise V

AU - Shrine, Nick

AU - Kalsheker, Noor

AU - Soler Artigas, Maria

AU - Repapi, Emmanouela

AU - Burton, Paul R

AU - Johnson, Toby

AU - Ramasamy, Adaikalavan

AU - Zhao, Jing Hua

AU - Zhai, Guangju

AU - Huffman, Jennifer E

AU - Vitart, Veronique

AU - Albrecht, Eva

AU - Igl, Wilmar

AU - Hartikainen, Anna-Liisa

AU - Pouta, Anneli

AU - Cadby, Gemma

AU - Hui, Jennie

AU - Palmer, Lyle J

AU - Hadley, David

AU - McArdle, Wendy L

AU - Rudnicka, Alicja R

AU - Barroso, Inês

AU - Loos, Ruth J F

AU - Wareham, Nicholas J

AU - Mangino, Massimo

AU - Soranzo, Nicole

AU - Spector, Tim D

AU - Gläser, Sven

AU - Homuth, Georg

AU - Völzke, Henry

AU - Deloukas, Panos

AU - Granell, Raquel

AU - Henderson, John

AU - Grkovic, Ivica

AU - Jankovic, Stipan

AU - Zgaga, Lina

AU - Polašek, Ozren

AU - Rudan, Igor

AU - Wright, Alan F

AU - Campbell, Harry

AU - Wild, Sarah H

AU - Wilson, James F

AU - Heinrich, Joachim

AU - Imboden, Medea

AU - Probst-Hensch, Nicole M

AU - Gyllensten, Ulf

AU - Johansson, Åsa

AU - Zaboli, Ghazal

AU - SpiroMeta Consortium

PY - 2011

Y1 - 2011

N2 - Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium).

AB - Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium).

U2 - 10.1371/journal.pone.0019382

DO - 10.1371/journal.pone.0019382

M3 - Article (Academic Journal)

C2 - 21625484

SN - 1932-6203

VL - 6

SP - e19382

JO - PLOS ONE

JF - PLOS ONE

IS - 5

ER -

A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample

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THE NATURAL HISTORY OF ASTHMA AND WHEEZING ILLNESSES FROM BIRTH TO ADOLESCENCE: DETERMINANTS OF THE REMISSION OF ASTHMA

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