A concise asymmetric route to the bridged bicyclic tropane alkaloid ferruginine using enyne ring-closing metathesis

VK Aggarwal*, CJ Astle, M Rogers-Evans

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

73 Citations (Scopus)

Abstract

Enyne metathesis has been used to prepare bridged azabicycles and applied in a short asymmetric synthesis of the tropane ferruginine. A Grubbs first generation catalyst proved to be superior to the second generation catalyst in the enyne metathesis reaction.

Original languageEnglish
Pages (from-to)1469-1471
Number of pages3
JournalOrganic Letters
Volume6
Issue number9
DOIs
Publication statusPublished - 29 Apr 2004

Keywords

  • RUTHENIUM CARBENE COMPLEXES
  • OLEFIN METATHESIS
  • AZABICYCLIC STRUCTURES
  • ORGANIC-SYNTHESIS
  • CATALYSTS
  • ALKYNES
  • ACID
  • (+)-FERRUGININE
  • PEPTIDOMIMETICS
  • DERIVATIVES

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