A concise asymmetric route to the bridged bicyclic tropane alkaloid ferruginine using enyne ring-closing metathesis

VK Aggarwal; CJ Astle; M Rogers-Evans

doi:10.1021/ol049665m

A concise asymmetric route to the bridged bicyclic tropane alkaloid ferruginine using enyne ring-closing metathesis

VK Aggarwal^*, CJ Astle, M Rogers-Evans

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

74 Citations (Scopus)

Abstract

Enyne metathesis has been used to prepare bridged azabicycles and applied in a short asymmetric synthesis of the tropane ferruginine. A Grubbs first generation catalyst proved to be superior to the second generation catalyst in the enyne metathesis reaction.

Original language	English
Pages (from-to)	1469-1471
Number of pages	3
Journal	Organic Letters
Volume	6
Issue number	9
DOIs	https://doi.org/10.1021/ol049665m
Publication status	Published - 29 Apr 2004

Keywords

RUTHENIUM CARBENE COMPLEXES
OLEFIN METATHESIS
AZABICYCLIC STRUCTURES
ORGANIC-SYNTHESIS
CATALYSTS
ALKYNES
ACID
(+)-FERRUGININE
PEPTIDOMIMETICS
DERIVATIVES

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title = "A concise asymmetric route to the bridged bicyclic tropane alkaloid ferruginine using enyne ring-closing metathesis",

abstract = "Enyne metathesis has been used to prepare bridged azabicycles and applied in a short asymmetric synthesis of the tropane ferruginine. A Grubbs first generation catalyst proved to be superior to the second generation catalyst in the enyne metathesis reaction.",

keywords = "RUTHENIUM CARBENE COMPLEXES, OLEFIN METATHESIS, AZABICYCLIC STRUCTURES, ORGANIC-SYNTHESIS, CATALYSTS, ALKYNES, ACID, (+)-FERRUGININE, PEPTIDOMIMETICS, DERIVATIVES",

author = "VK Aggarwal and CJ Astle and M Rogers-Evans",

year = "2004",

month = apr,

day = "29",

doi = "10.1021/ol049665m",

language = "English",

volume = "6",

pages = "1469--1471",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "9",

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TY - JOUR

T1 - A concise asymmetric route to the bridged bicyclic tropane alkaloid ferruginine using enyne ring-closing metathesis

AU - Aggarwal, VK

AU - Astle, CJ

AU - Rogers-Evans, M

PY - 2004/4/29

Y1 - 2004/4/29

N2 - Enyne metathesis has been used to prepare bridged azabicycles and applied in a short asymmetric synthesis of the tropane ferruginine. A Grubbs first generation catalyst proved to be superior to the second generation catalyst in the enyne metathesis reaction.

AB - Enyne metathesis has been used to prepare bridged azabicycles and applied in a short asymmetric synthesis of the tropane ferruginine. A Grubbs first generation catalyst proved to be superior to the second generation catalyst in the enyne metathesis reaction.

KW - RUTHENIUM CARBENE COMPLEXES

KW - OLEFIN METATHESIS

KW - AZABICYCLIC STRUCTURES

KW - ORGANIC-SYNTHESIS

KW - CATALYSTS

KW - ALKYNES

KW - ACID

KW - (+)-FERRUGININE

KW - PEPTIDOMIMETICS

KW - DERIVATIVES

U2 - 10.1021/ol049665m

DO - 10.1021/ol049665m

M3 - Article (Academic Journal)

SN - 1523-7060

VL - 6

SP - 1469

EP - 1471

JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

A concise asymmetric route to the bridged bicyclic tropane alkaloid ferruginine using enyne ring-closing metathesis

Abstract

Keywords

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