A disorder of cortical GABAergic innervation in Alzheimer's disease

J Hardy, R Cowburn, A Barton, G Reynolds, P Dodd, P Wester, A M O'Carroll, E Lofdahl, B Winblad

Research output: Contribution to journalArticle (Academic Journal)peer-review

100 Citations (Scopus)


Synaptosomal gamma-aminobutyric acid (GABA) uptake has been used as a biochemical marker for GABAergic terminals in controls and Alzheimer disease brains. Use of this marker suggests a large (ca. 70%) loss of cortical and hippocampal GABA terminals in Alzheimer brain. To explain this observation we suggest that neuron loss in this disorder occurs via a process of cortical retrograde degeneration. This scheme reconciles our findings with previous neurochemical measurements on Alzheimer disease brains and also better reconciles the biochemistry with the histology of the disorder.

Original languageEnglish
Pages (from-to)192-6
Number of pages5
JournalNeuroscience Letters
Issue number2
Publication statusPublished - 14 Jan 1987


  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Cerebral Cortex
  • Female
  • Hippocampus
  • Humans
  • Male
  • Middle Aged
  • Synaptosomes
  • gamma-Aminobutyric Acid


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