A disorder of cortical GABAergic innervation in Alzheimer's disease

J Hardy; R Cowburn; A Barton; G Reynolds; P Dodd; P Wester; A M O'Carroll; E Lofdahl; B Winblad

A disorder of cortical GABAergic innervation in Alzheimer's disease

J Hardy
, R Cowburn
, A Barton
, G Reynolds
, P Dodd
, P Wester
, A M O'Carroll
, E Lofdahl
, B Winblad

Research output: Contribution to journal › Article (Academic Journal) › peer-review

104 Citations (Scopus)

Abstract

Synaptosomal gamma-aminobutyric acid (GABA) uptake has been used as a biochemical marker for GABAergic terminals in controls and Alzheimer disease brains. Use of this marker suggests a large (ca. 70%) loss of cortical and hippocampal GABA terminals in Alzheimer brain. To explain this observation we suggest that neuron loss in this disorder occurs via a process of cortical retrograde degeneration. This scheme reconciles our findings with previous neurochemical measurements on Alzheimer disease brains and also better reconciles the biochemistry with the histology of the disorder.

Original language	English
Pages (from-to)	192-6
Number of pages	5
Journal	Neuroscience Letters
Volume	73
Issue number	2
Publication status	Published - 14 Jan 1987

Keywords

Aged
Aged, 80 and over
Alzheimer Disease
Cerebral Cortex
Female
Hippocampus
Humans
Male
Middle Aged
Synaptosomes
gamma-Aminobutyric Acid

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title = "A disorder of cortical GABAergic innervation in Alzheimer's disease",

abstract = "Synaptosomal gamma-aminobutyric acid (GABA) uptake has been used as a biochemical marker for GABAergic terminals in controls and Alzheimer disease brains. Use of this marker suggests a large (ca. 70\%) loss of cortical and hippocampal GABA terminals in Alzheimer brain. To explain this observation we suggest that neuron loss in this disorder occurs via a process of cortical retrograde degeneration. This scheme reconciles our findings with previous neurochemical measurements on Alzheimer disease brains and also better reconciles the biochemistry with the histology of the disorder.",

keywords = "Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Female, Hippocampus, Humans, Male, Middle Aged, Synaptosomes, gamma-Aminobutyric Acid",

author = "J Hardy and R Cowburn and A Barton and G Reynolds and P Dodd and P Wester and O'Carroll, \{A M\} and E Lofdahl and B Winblad",

year = "1987",

month = jan,

day = "14",

language = "English",

volume = "73",

pages = "192--6",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Science Ireland",

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}

TY - JOUR

T1 - A disorder of cortical GABAergic innervation in Alzheimer's disease

AU - Hardy, J

AU - Cowburn, R

AU - Barton, A

AU - Reynolds, G

AU - Dodd, P

AU - Wester, P

AU - O'Carroll, A M

AU - Lofdahl, E

AU - Winblad, B

PY - 1987/1/14

Y1 - 1987/1/14

N2 - Synaptosomal gamma-aminobutyric acid (GABA) uptake has been used as a biochemical marker for GABAergic terminals in controls and Alzheimer disease brains. Use of this marker suggests a large (ca. 70%) loss of cortical and hippocampal GABA terminals in Alzheimer brain. To explain this observation we suggest that neuron loss in this disorder occurs via a process of cortical retrograde degeneration. This scheme reconciles our findings with previous neurochemical measurements on Alzheimer disease brains and also better reconciles the biochemistry with the histology of the disorder.

AB - Synaptosomal gamma-aminobutyric acid (GABA) uptake has been used as a biochemical marker for GABAergic terminals in controls and Alzheimer disease brains. Use of this marker suggests a large (ca. 70%) loss of cortical and hippocampal GABA terminals in Alzheimer brain. To explain this observation we suggest that neuron loss in this disorder occurs via a process of cortical retrograde degeneration. This scheme reconciles our findings with previous neurochemical measurements on Alzheimer disease brains and also better reconciles the biochemistry with the histology of the disorder.

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease

KW - Cerebral Cortex

KW - Female

KW - Hippocampus

KW - Humans

KW - Male

KW - Middle Aged

KW - Synaptosomes

KW - gamma-Aminobutyric Acid

M3 - Article (Academic Journal)

C2 - 3822251

SN - 0304-3940

VL - 73

SP - 192

EP - 196

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

A disorder of cortical GABAergic innervation in Alzheimer's disease

Abstract

Keywords

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