TY - JOUR
T1 - A general synthetic approach to the amnesic shellfish toxins
T2 - Total synthesis of (-)-isodomoic acid B, (-)-isodomoic acid E and (-)-isodomoic acid F
AU - Lemière, Gilles
AU - Sedehizadeh, Simon
AU - Toueg, Julie
AU - Fleary-Roberts, Nadia
AU - Clayden, Jonathan
PY - 2011/4/7
Y1 - 2011/4/7
N2 - The alkynylpyrrolidine 4 was made via a dearomatising cyclisation of an aromatic amide, and was elaborated by stannylcupration and palladium-catalysed coupling to achieve the first total synthesis of three members of the isodomoic acid family; the same alkyne can be envisaged as a precursor to several more of this class of amnesic shellfish toxins.
AB - The alkynylpyrrolidine 4 was made via a dearomatising cyclisation of an aromatic amide, and was elaborated by stannylcupration and palladium-catalysed coupling to achieve the first total synthesis of three members of the isodomoic acid family; the same alkyne can be envisaged as a precursor to several more of this class of amnesic shellfish toxins.
UR - http://www.scopus.com/inward/record.url?scp=79952661462&partnerID=8YFLogxK
U2 - 10.1039/c1cc00048a
DO - 10.1039/c1cc00048a
M3 - Article (Academic Journal)
C2 - 21350768
AN - SCOPUS:79952661462
VL - 47
SP - 3745
EP - 3747
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 13
ER -