A general synthetic approach to the amnesic shellfish toxins: Total synthesis of (-)-isodomoic acid B, (-)-isodomoic acid E and (-)-isodomoic acid F

Gilles Lemière, Simon Sedehizadeh, Julie Toueg, Nadia Fleary-Roberts, Jonathan Clayden*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

27 Citations (Scopus)

Abstract

The alkynylpyrrolidine 4 was made via a dearomatising cyclisation of an aromatic amide, and was elaborated by stannylcupration and palladium-catalysed coupling to achieve the first total synthesis of three members of the isodomoic acid family; the same alkyne can be envisaged as a precursor to several more of this class of amnesic shellfish toxins.

Original languageEnglish
Pages (from-to)3745-3747
Number of pages3
JournalChemical Communications
Volume47
Issue number13
Early online date24 Feb 2011
DOIs
Publication statusPublished - 7 Apr 2011

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