A genetic risk score and number of myopic parents independently predict myopia

Neema Ghorbani Mojarrad, Cathy E M Williams, Jeremy Guggenheim*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)
177 Downloads (Pure)

Abstract

PURPOSE. To investigate whether a genetic risk score (GRS) improved performance of predicting refractive error compared to knowing a child’s number of myopic parents (NMP) alone.
METHODS. This was a retrospective analysis of data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort study. Refractive error was assessed longitudinally between age 7-15 using noncycloplegic autorefraction. Genetic variants (n=149) associated with refractive error from a CREAM consortium genome-wide association study were used to calculate a GRS for each child. Using refractive error at ages 7 and 15 years as the outcome variable, coefficient of determination (R2) values were calculated via linear regression models for the predictors: NMP, GRS and a combined model.
RESULTS. NMP was weakly predictive of refractive error in children aged 7 years, R2 = 3.0% (95% CI 1.8-4.1%, P<0.0001) and aged 15 years, R2 = 4.8% (3.1-6.5%, P<0.0001). The GRS was also weakly predictive; age 7 years, R2 = 1.1% (0.0-1.9%, P<0.0001) and 15 years R2 = 2.6% (1.3-3.9%, P<0.0001). Combining the 2 variables gave larger R2 values at ages 7, R2 =3.7% (2.5-5.0%, P<0.0001) and 15, R2 = 7.0% (5.0-9.0%, P<0.0001). The combined model improved performance at both ages (both P<0.0001).
CONCLUSION. A GRS improved the ability to detect children at risk of myopia independently of knowing the NMP. We speculate this may be because NMP captures information concerning environmental risk factors for myopia. Nevertheless, further gains are required to make such predictive tests worthwhile in the clinical environment.
Original languageEnglish
Number of pages11
JournalOphthalmic and Physiological Optics
Early online date4 Sep 2018
DOIs
Publication statusE-pub ahead of print - 4 Sep 2018

Keywords

  • Refractive error
  • myopia
  • genetic prediction
  • ALSPAC

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