A genome-wide association meta-analysis identifies new childhood obesity loci

Jonathan P Bradfield; H Rob Taal; Nicholas J Timpson; André Scherag; Cecile Lecoeur; Nicole M Warrington; Elina Hypponen; Claus Holst; Beatriz Valcarcel; Elisabeth Thiering; Rany M Salem; Fredrick R Schumacher; Diana L Cousminer; Patrick M A Sleiman; Jianhua Zhao; Robert I Berkowitz; Karani S Vimaleswaran; Ivonne Jarick; Craig E Pennell; David M Evans; Beate St Pourcain; Diane J Berry; Dennis O Mook-Kanamori; Albert Hofman; Fernando Rivadeneira; André G Uitterlinden; Cornelia M van Duijn; Ralf J P van der Valk; Johan C de Jongste; Dirkje S Postma; Dorret I Boomsma; W James Gauderman; Mohamed T Hassanein; Cecilia M Lindgren; Reedik Mägi; Colin A G Boreham; Charlotte E Neville; Luis A Moreno; Paul Elliott; Anneli Pouta; Anna-Liisa Hartikainen; Mingyao Li; Olli Raitakari; Terho Lehtimäki; George McMahon; Susan M Ring; John P Kemp; Thorkild Sorensen; Lyle J Palmer; George Davey Smith; Early Growth Genetics Consortium

doi:10.1038/ng.2247

A genome-wide association meta-analysis identifies new childhood obesity loci

Jonathan P Bradfield, H Rob Taal, Nicholas J Timpson, André Scherag, Cecile Lecoeur, Nicole M Warrington, Elina Hypponen, Claus Holst, Beatriz Valcarcel, Elisabeth Thiering, Rany M Salem, Fredrick R Schumacher, Diana L Cousminer, Patrick M A Sleiman, Jianhua Zhao, Robert I Berkowitz, Karani S Vimaleswaran, Ivonne Jarick, Craig E Pennell, David M EvansBeate St Pourcain, Diane J Berry, Dennis O Mook-Kanamori, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Cornelia M van Duijn, Ralf J P van der Valk, Johan C de Jongste, Dirkje S Postma, Dorret I Boomsma, W James Gauderman, Mohamed T Hassanein, Cecilia M Lindgren, Reedik Mägi, Colin A G Boreham, Charlotte E Neville, Luis A Moreno, Paul Elliott, Anneli Pouta, Anna-Liisa Hartikainen, Mingyao Li, Olli Raitakari, Terho Lehtimäki, George McMahon, Susan M Ring, John P Kemp, Thorkild Sorensen, Lyle J Palmer, George Davey Smith, Early Growth Genetics Consortium

Research output: Contribution to journal › Article (Academic Journal) › peer-review

272 Citations (Scopus)

Abstract

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (

Original language	English
Pages (from-to)	526-31
Number of pages	6
Journal	Nature Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1038/ng.2247
Publication status	Published - 2012

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B603 THE EFFECT OF COMMON DISEASE ASSOCIATED GENETIC VARIANTS ON TRANSCRIPTOMIC AND EARLY LIFE PHENOTYPES
Evans, D.
1/09/08 → 1/09/11
Project: Research
CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)
Davey Smith, G.
1/09/07 → 1/09/13
Project: Research

1 Advisory work for/on national or international committee or working group

EAGLE/EGG (External organisation)
M U B St Pourcain (Member)
2010 → …
Activity: Membership types › Advisory work for/on national or international committee or working group

Cite this

Bradfield, J. P., Taal, H. R., Timpson, N. J., Scherag, A., Lecoeur, C., Warrington, N. M., Hypponen, E., Holst, C., Valcarcel, B., Thiering, E., Salem, R. M., Schumacher, F. R., Cousminer, D. L., Sleiman, P. M. A., Zhao, J., Berkowitz, R. I., Vimaleswaran, K. S., Jarick, I., Pennell, C. E., ... Early Growth Genetics Consortium (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44(5), 526-31. https://doi.org/10.1038/ng.2247

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Bradfield, JP, Taal, HR, Timpson, NJ, Scherag, A, Lecoeur, C, Warrington, NM, Hypponen, E, Holst, C, Valcarcel, B, Thiering, E, Salem, RM, Schumacher, FR, Cousminer, DL, Sleiman, PMA, Zhao, J, Berkowitz, RI, Vimaleswaran, KS, Jarick, I, Pennell, CE, Evans, DM, St Pourcain, B, Berry, DJ, Mook-Kanamori, DO, Hofman, A, Rivadeneira, F, Uitterlinden, AG, van Duijn, CM, van der Valk, RJP, de Jongste, JC, Postma, DS, Boomsma, DI, Gauderman, WJ, Hassanein, MT, Lindgren, CM, Mägi, R, Boreham, CAG, Neville, CE, Moreno, LA, Elliott, P, Pouta, A, Hartikainen, A-L, Li, M, Raitakari, O, Lehtimäki, T, McMahon, G, Ring, SM, Kemp, JP, Sorensen, T, Palmer, LJ, Smith, GD & Early Growth Genetics Consortium 2012, 'A genome-wide association meta-analysis identifies new childhood obesity loci', Nature Genetics, vol. 44, no. 5, pp. 526-31. https://doi.org/10.1038/ng.2247

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AB - Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (

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SP - 526

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JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

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A genome-wide association meta-analysis identifies new childhood obesity loci

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B603 THE EFFECT OF COMMON DISEASE ASSOCIATED GENETIC VARIANTS ON TRANSCRIPTOMIC AND EARLY LIFE PHENOTYPES

CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)

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