A genome-wide association meta-analysis identifies new childhood obesity loci

Jonathan P Bradfield; H Rob Taal; Nicholas J Timpson; André Scherag; Cecile Lecoeur; Nicole M Warrington; Elina Hypponen; Claus Holst; Beatriz Valcarcel; Elisabeth Thiering; Rany M Salem; Fredrick R Schumacher; Diana L Cousminer; Patrick M A Sleiman; Jianhua Zhao; Robert I Berkowitz; Karani S Vimaleswaran; Ivonne Jarick; Craig E Pennell; David M Evans; Beate St Pourcain; Diane J Berry; Dennis O Mook-Kanamori; Albert Hofman; Fernando Rivadeneira; André G Uitterlinden; Cornelia M van Duijn; Ralf J P van der Valk; Johan C de Jongste; Dirkje S Postma; Dorret I Boomsma; W James Gauderman; Mohamed T Hassanein; Cecilia M Lindgren; Reedik Mägi; Colin A G Boreham; Charlotte E Neville; Luis A Moreno; Paul Elliott; Anneli Pouta; Anna-Liisa Hartikainen; Mingyao Li; Olli Raitakari; Terho Lehtimäki; George McMahon; Susan M Ring; John P Kemp; Thorkild Sorensen; Lyle J Palmer; George Davey Smith; Early Growth Genetics Consortium

doi:10.1038/ng.2247

A genome-wide association meta-analysis identifies new childhood obesity loci

Jonathan P Bradfield, H Rob Taal, Nicholas J Timpson, André Scherag, Cecile Lecoeur, Nicole M Warrington, Elina Hypponen, Claus Holst, Beatriz Valcarcel, Elisabeth Thiering, Rany M Salem, Fredrick R Schumacher, Diana L Cousminer, Patrick M A Sleiman, Jianhua Zhao, Robert I Berkowitz, Karani S Vimaleswaran, Ivonne Jarick, Craig E Pennell, David M EvansBeate St Pourcain, Diane J Berry, Dennis O Mook-Kanamori, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Cornelia M van Duijn, Ralf J P van der Valk, Johan C de Jongste, Dirkje S Postma, Dorret I Boomsma, W James Gauderman, Mohamed T Hassanein, Cecilia M Lindgren, Reedik Mägi, Colin A G Boreham, Charlotte E Neville, Luis A Moreno, Paul Elliott, Anneli Pouta, Anna-Liisa Hartikainen, Mingyao Li, Olli Raitakari, Terho Lehtimäki, George McMahon, Susan M Ring, John P Kemp, Thorkild Sorensen, Lyle J Palmer, George Davey Smith, Early Growth Genetics Consortium

Research output: Contribution to journal › Article (Academic Journal) › peer-review

247 Citations (Scopus)

Abstract

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (

Original language	English
Pages (from-to)	526-31
Number of pages	6
Journal	Nature Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1038/ng.2247
Publication status	Published - 2012

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10.1038/ng.2247

2 Finished

B603 THE EFFECT OF COMMON DISEASE ASSOCIATED GENETIC VARIANTS ON TRANSCRIPTOMIC AND EARLY LIFE PHENOTYPES
Evans, D.
1/09/08 → 1/09/11
Project: Research
CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)
Davey Smith, G.
1/09/07 → 1/09/13
Project: Research

1 Advisory work for/on national or international committee or working group

EAGLE/EGG (External organisation)
M U B St Pourcain (Member)
2010 → …
Activity: Membership types › Advisory work for/on national or international committee or working group

Cite this

Bradfield, J. P., Taal, H. R., Timpson, N. J., Scherag, A., Lecoeur, C., Warrington, N. M., Hypponen, E., Holst, C., Valcarcel, B., Thiering, E., Salem, R. M., Schumacher, F. R., Cousminer, D. L., Sleiman, P. M. A., Zhao, J., Berkowitz, R. I., Vimaleswaran, K. S., Jarick, I., Pennell, C. E., ... Early Growth Genetics Consortium (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44(5), 526-31. https://doi.org/10.1038/ng.2247

Bradfield, Jonathan P ; Taal, H Rob ; Timpson, Nicholas J ; Scherag, André ; Lecoeur, Cecile ; Warrington, Nicole M ; Hypponen, Elina ; Holst, Claus ; Valcarcel, Beatriz ; Thiering, Elisabeth ; Salem, Rany M ; Schumacher, Fredrick R ; Cousminer, Diana L ; Sleiman, Patrick M A ; Zhao, Jianhua ; Berkowitz, Robert I ; Vimaleswaran, Karani S ; Jarick, Ivonne ; Pennell, Craig E ; Evans, David M ; St Pourcain, Beate ; Berry, Diane J ; Mook-Kanamori, Dennis O ; Hofman, Albert ; Rivadeneira, Fernando ; Uitterlinden, André G ; van Duijn, Cornelia M ; van der Valk, Ralf J P ; de Jongste, Johan C ; Postma, Dirkje S ; Boomsma, Dorret I ; Gauderman, W James ; Hassanein, Mohamed T ; Lindgren, Cecilia M ; Mägi, Reedik ; Boreham, Colin A G ; Neville, Charlotte E ; Moreno, Luis A ; Elliott, Paul ; Pouta, Anneli ; Hartikainen, Anna-Liisa ; Li, Mingyao ; Raitakari, Olli ; Lehtimäki, Terho ; McMahon, George ; Ring, Susan M ; Kemp, John P ; Sorensen, Thorkild ; Palmer, Lyle J ; Smith, George Davey ; Early Growth Genetics Consortium. / A genome-wide association meta-analysis identifies new childhood obesity loci. In: Nature Genetics. 2012 ; Vol. 44, No. 5. pp. 526-31.

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Bradfield, JP, Taal, HR, Timpson, NJ, Scherag, A, Lecoeur, C, Warrington, NM, Hypponen, E, Holst, C, Valcarcel, B, Thiering, E, Salem, RM, Schumacher, FR, Cousminer, DL, Sleiman, PMA, Zhao, J, Berkowitz, RI, Vimaleswaran, KS, Jarick, I, Pennell, CE, Evans, DM, St Pourcain, B, Berry, DJ, Mook-Kanamori, DO, Hofman, A, Rivadeneira, F, Uitterlinden, AG, van Duijn, CM, van der Valk, RJP, de Jongste, JC, Postma, DS, Boomsma, DI, Gauderman, WJ, Hassanein, MT, Lindgren, CM, Mägi, R, Boreham, CAG, Neville, CE, Moreno, LA, Elliott, P, Pouta, A, Hartikainen, A-L, Li, M, Raitakari, O, Lehtimäki, T, McMahon, G, Ring, SM, Kemp, JP, Sorensen, T, Palmer, LJ, Smith, GD & Early Growth Genetics Consortium 2012, 'A genome-wide association meta-analysis identifies new childhood obesity loci', Nature Genetics, vol. 44, no. 5, pp. 526-31. https://doi.org/10.1038/ng.2247

A genome-wide association meta-analysis identifies new childhood obesity loci. / Bradfield, Jonathan P; Taal, H Rob; Timpson, Nicholas J; Scherag, André; Lecoeur, Cecile; Warrington, Nicole M; Hypponen, Elina; Holst, Claus; Valcarcel, Beatriz; Thiering, Elisabeth; Salem, Rany M; Schumacher, Fredrick R; Cousminer, Diana L; Sleiman, Patrick M A; Zhao, Jianhua; Berkowitz, Robert I; Vimaleswaran, Karani S; Jarick, Ivonne; Pennell, Craig E; Evans, David M; St Pourcain, Beate; Berry, Diane J; Mook-Kanamori, Dennis O; Hofman, Albert; Rivadeneira, Fernando; Uitterlinden, André G; van Duijn, Cornelia M; van der Valk, Ralf J P; de Jongste, Johan C; Postma, Dirkje S; Boomsma, Dorret I; Gauderman, W James; Hassanein, Mohamed T; Lindgren, Cecilia M; Mägi, Reedik; Boreham, Colin A G; Neville, Charlotte E; Moreno, Luis A; Elliott, Paul; Pouta, Anneli; Hartikainen, Anna-Liisa; Li, Mingyao; Raitakari, Olli; Lehtimäki, Terho; McMahon, George; Ring, Susan M; Kemp, John P; Sorensen, Thorkild; Palmer, Lyle J; Smith, George Davey; Early Growth Genetics Consortium.

In: Nature Genetics, Vol. 44, No. 5, 2012, p. 526-31.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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AU - Taal, H Rob

AU - Timpson, Nicholas J

AU - Scherag, André

AU - Lecoeur, Cecile

AU - Warrington, Nicole M

AU - Hypponen, Elina

AU - Holst, Claus

AU - Valcarcel, Beatriz

AU - Thiering, Elisabeth

AU - Salem, Rany M

AU - Schumacher, Fredrick R

AU - Cousminer, Diana L

AU - Sleiman, Patrick M A

AU - Zhao, Jianhua

AU - Berkowitz, Robert I

AU - Vimaleswaran, Karani S

AU - Jarick, Ivonne

AU - Pennell, Craig E

AU - Evans, David M

AU - St Pourcain, Beate

AU - Berry, Diane J

AU - Mook-Kanamori, Dennis O

AU - Hofman, Albert

AU - Rivadeneira, Fernando

AU - Uitterlinden, André G

AU - van Duijn, Cornelia M

AU - van der Valk, Ralf J P

AU - de Jongste, Johan C

AU - Postma, Dirkje S

AU - Boomsma, Dorret I

AU - Gauderman, W James

AU - Hassanein, Mohamed T

AU - Lindgren, Cecilia M

AU - Mägi, Reedik

AU - Boreham, Colin A G

AU - Neville, Charlotte E

AU - Moreno, Luis A

AU - Elliott, Paul

AU - Pouta, Anneli

AU - Hartikainen, Anna-Liisa

AU - Li, Mingyao

AU - Raitakari, Olli

AU - Lehtimäki, Terho

AU - McMahon, George

AU - Ring, Susan M

AU - Kemp, John P

AU - Sorensen, Thorkild

AU - Palmer, Lyle J

AU - Smith, George Davey

AU - Early Growth Genetics Consortium

PY - 2012

Y1 - 2012

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AB - Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (

U2 - 10.1038/ng.2247

DO - 10.1038/ng.2247

M3 - Article (Academic Journal)

C2 - 22484627

VL - 44

SP - 526

EP - 531

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 5

ER -

A genome-wide association meta-analysis identifies new childhood obesity loci

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B603 THE EFFECT OF COMMON DISEASE ASSOCIATED GENETIC VARIANTS ON TRANSCRIPTOMIC AND EARLY LIFE PHENOTYPES

CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)

Activities

EAGLE/EGG (External organisation)

Cite this