A genome-wide association meta-analysis identifies new childhood obesity loci

Jonathan P Bradfield; H Rob Taal; Nicholas J Timpson; André Scherag; Cecile Lecoeur; Nicole M Warrington; Elina Hypponen; Claus Holst; Beatriz Valcarcel; Elisabeth Thiering; Rany M Salem; Fredrick R Schumacher; Diana L Cousminer; Patrick M A Sleiman; Jianhua Zhao; Robert I Berkowitz; Karani S Vimaleswaran; Ivonne Jarick; Craig E Pennell; David M Evans; Beate St Pourcain; Diane J Berry; Dennis O Mook-Kanamori; Albert Hofman; Fernando Rivadeneira; André G Uitterlinden; Cornelia M van Duijn; Ralf J P van der Valk; Johan C de Jongste; Dirkje S Postma; Dorret I Boomsma; W James Gauderman; Mohamed T Hassanein; Cecilia M Lindgren; Reedik Mägi; Colin A G Boreham; Charlotte E Neville; Luis A Moreno; Paul Elliott; Anneli Pouta; Anna-Liisa Hartikainen; Mingyao Li; Olli Raitakari; Terho Lehtimäki; George McMahon; Susan M Ring; John P Kemp; Thorkild Sorensen; Lyle J Palmer; George Davey Smith; Early Growth Genetics Consortium

doi:10.1038/ng.2247

A genome-wide association meta-analysis identifies new childhood obesity loci

Jonathan P Bradfield
, H Rob Taal
, Nicholas J Timpson
, André Scherag
, Cecile Lecoeur
, Nicole M Warrington
, Elina Hypponen
, Claus Holst
, Beatriz Valcarcel
, Elisabeth Thiering
, Rany M Salem
, Fredrick R Schumacher
, Diana L Cousminer
, Patrick M A Sleiman
, Jianhua Zhao
, Robert I Berkowitz
, Karani S Vimaleswaran
, Ivonne Jarick
, Craig E Pennell
, David M Evans

Beate St Pourcain, Diane J Berry, Dennis O Mook-Kanamori, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Cornelia M van Duijn, Ralf J P van der Valk, Johan C de Jongste, Dirkje S Postma, Dorret I Boomsma, W James Gauderman, Mohamed T Hassanein, Cecilia M Lindgren, Reedik Mägi, Colin A G Boreham, Charlotte E Neville, Luis A Moreno, Paul Elliott, Anneli Pouta, Anna-Liisa Hartikainen, Mingyao Li, Olli Raitakari, Terho Lehtimäki, George McMahon, Susan M Ring, John P Kemp, Thorkild Sorensen, Lyle J Palmer, George Davey Smith, Early Growth Genetics Consortium

Research output: Contribution to journal › Article (Academic Journal) › peer-review

361 Citations (Scopus)

Abstract

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (

Original language	English
Pages (from-to)	526-31
Number of pages	6
Journal	Nature Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1038/ng.2247
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/ng.2247

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B603 THE EFFECT OF COMMON DISEASE ASSOCIATED GENETIC VARIANTS ON TRANSCRIPTOMIC AND EARLY LIFE PHENOTYPES
Evans, D. (Principal Investigator)
1/09/08 → 1/09/11
Project: Research
CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)
Davey Smith, G. (Principal Investigator)
1/09/07 → 1/09/13
Project: Research

EAGLE/EGG (External organisation)
St Pourcain, M. U. B. (Member)
2010 → …
Activity: Membership types › Advisory work for/on national or international committee or working group

Cite this

Bradfield, J. P., Taal, H. R., Timpson, N. J., Scherag, A., Lecoeur, C., Warrington, N. M., Hypponen, E., Holst, C., Valcarcel, B., Thiering, E., Salem, R. M., Schumacher, F. R., Cousminer, D. L., Sleiman, P. M. A., Zhao, J., Berkowitz, R. I., Vimaleswaran, K. S., Jarick, I., Pennell, C. E., ... Early Growth Genetics Consortium (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44(5), 526-31. https://doi.org/10.1038/ng.2247

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doi = "10.1038/ng.2247",

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volume = "44",

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Bradfield, JP, Taal, HR, Timpson, NJ, Scherag, A, Lecoeur, C, Warrington, NM, Hypponen, E, Holst, C, Valcarcel, B, Thiering, E, Salem, RM, Schumacher, FR, Cousminer, DL, Sleiman, PMA, Zhao, J, Berkowitz, RI, Vimaleswaran, KS, Jarick, I, Pennell, CE, Evans, DM, St Pourcain, B, Berry, DJ, Mook-Kanamori, DO, Hofman, A, Rivadeneira, F, Uitterlinden, AG, van Duijn, CM, van der Valk, RJP, de Jongste, JC, Postma, DS, Boomsma, DI, Gauderman, WJ, Hassanein, MT, Lindgren, CM, Mägi, R, Boreham, CAG, Neville, CE, Moreno, LA, Elliott, P, Pouta, A, Hartikainen, A-L, Li, M, Raitakari, O, Lehtimäki, T, McMahon, G, Ring, SM, Kemp, JP, Sorensen, T, Palmer, LJ, Smith, GD & Early Growth Genetics Consortium 2012, 'A genome-wide association meta-analysis identifies new childhood obesity loci', Nature Genetics, vol. 44, no. 5, pp. 526-31. https://doi.org/10.1038/ng.2247

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AU - Hypponen, Elina

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AU - Raitakari, Olli

AU - Lehtimäki, Terho

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AU - Kemp, John P

AU - Sorensen, Thorkild

AU - Palmer, Lyle J

AU - Smith, George Davey

AU - Early Growth Genetics Consortium

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AB - Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (

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DO - 10.1038/ng.2247

M3 - Article (Academic Journal)

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SN - 1546-1718

VL - 44

SP - 526

EP - 531

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

A genome-wide association meta-analysis identifies new childhood obesity loci

Abstract

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B603 THE EFFECT OF COMMON DISEASE ASSOCIATED GENETIC VARIANTS ON TRANSCRIPTOMIC AND EARLY LIFE PHENOTYPES

CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)

Activities

EAGLE/EGG (External organisation)

Cite this