Projects per year
Abstract
Allergic disease is very common and carries substantial public-health burdens. We conducted a meta-analysis of genome-wide associations with self-reported cat, dust-mite and pollen allergies in 53,862 individuals. We used generalized estimating equations to model shared and allergy-specific genetic effects. We identified 16 shared susceptibility loci with association P <5 × 10(-8), including 8 loci previously associated with asthma, as well as 4p14 near TLR1, TLR6 and TLR10 (rs2101521, P = 5.3 × 10(-21)); 6p21.33 near HLA-C and MICA (rs9266772, P = 3.2 × 10(-12)); 5p13.1 near PTGER4 (rs7720838, P = 8.2 × 10(-11)); 2q33.1 in PLCL1 (rs10497813, P = 6.1 × 10(-10)), 3q28 in LPP (rs9860547, P = 1.2 × 10(-9)); 20q13.2 in NFATC2 (rs6021270, P = 6.9 × 10(-9)), 4q27 in ADAD1 (rs17388568, P = 3.9 × 10(-8)); and 14q21.1 near FOXA1 and TTC6 (rs1998359, P = 4.8 × 10(-8)). We identified one locus with substantial evidence of differences in effects across allergies at 6p21.32 in the class II human leukocyte antigen (HLA) region (rs17533090, P = 1.7 × 10(-12)), which was strongly associated with cat allergy. Our study sheds new light on the shared etiology of immune and autoimmune disease.
Original language | English |
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Journal | Nature Genetics |
Early online date | 30 Jun 2013 |
DOIs | |
Publication status | Published - 30 Jun 2013 |
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Dive into the research topics of 'A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci'. Together they form a unique fingerprint.Projects
- 3 Finished
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MRC UoB UNITE Unit - Programme 1
Davey Smith, G. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
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MRC UoB UNITE Unit - programme 3
Timpson, N. J. (Principal Investigator) & Timpson, N. J. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
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