A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

David A Hinds, George McMahon, Amy K Kiefer, Chuong B Do, Nicholas Eriksson, David M Evans, Beate St Pourcain, Susan M Ring, Joanna L Mountain, Uta Francke, George Davey Smith, Nicholas J Timpson, Joyce Y Tung

Research output: Contribution to journalArticle (Academic Journal)peer-review

161 Citations (Scopus)

Abstract

Allergic disease is very common and carries substantial public-health burdens. We conducted a meta-analysis of genome-wide associations with self-reported cat, dust-mite and pollen allergies in 53,862 individuals. We used generalized estimating equations to model shared and allergy-specific genetic effects. We identified 16 shared susceptibility loci with association P <5 × 10(-8), including 8 loci previously associated with asthma, as well as 4p14 near TLR1, TLR6 and TLR10 (rs2101521, P = 5.3 × 10(-21)); 6p21.33 near HLA-C and MICA (rs9266772, P = 3.2 × 10(-12)); 5p13.1 near PTGER4 (rs7720838, P = 8.2 × 10(-11)); 2q33.1 in PLCL1 (rs10497813, P = 6.1 × 10(-10)), 3q28 in LPP (rs9860547, P = 1.2 × 10(-9)); 20q13.2 in NFATC2 (rs6021270, P = 6.9 × 10(-9)), 4q27 in ADAD1 (rs17388568, P = 3.9 × 10(-8)); and 14q21.1 near FOXA1 and TTC6 (rs1998359, P = 4.8 × 10(-8)). We identified one locus with substantial evidence of differences in effects across allergies at 6p21.32 in the class II human leukocyte antigen (HLA) region (rs17533090, P = 1.7 × 10(-12)), which was strongly associated with cat allergy. Our study sheds new light on the shared etiology of immune and autoimmune disease.
Original languageEnglish
JournalNature Genetics
Early online date30 Jun 2013
DOIs
Publication statusPublished - 30 Jun 2013

Fingerprint Dive into the research topics of 'A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci'. Together they form a unique fingerprint.

Cite this