A genome-wide association search for type 2 diabetes genes in African Americans

Nicholette D Palmer, Caitrin W McDonough, Pamela J Hicks, Bong H Roh, Maria R Wing, S Sandy An, Jessica M Hester, Jessica N Cooke, Meredith A Bostrom, Megan E Rudock, Matthew E Talbert, Joshua P Lewis, Assiamira Ferrara, Lingyi Lu, Julie T Ziegler, Michele M Sale, Jasmin Divers, Daniel Shriner, Adebowale Adeyemo, Charles N RotimiMaggie C Y Ng, Carl D Langefeld, Barry I Freedman, Donald W Bowden, Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, Ryan P Welch, Eleftheria Zeggini, Cornelia Huth, Yurii S Aulchenko, Gudmar Thorleifsson, Laura J McCulloch, Teresa Ferreira, Harald Grallert, Najaf Amin, Guanming Wu, Cristen J Willer, Paul R V Johnson, Meena Kumari, Nicholas J Timpson, Yoav Ben-Shlomo, Ian N M Day, Mika Kivimaki, Debbie A Lawlor, George Davey Smith, Lyle J Palmer, Shah Ebrahim, DIAGRAM Consortium

Research output: Contribution to journalArticle (Academic Journal)peer-review

130 Citations (Scopus)

Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P
Original languageEnglish
Pages (from-to)e29202
JournalPLoS ONE
Volume7
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • Polymorphism, Single Nucleotide
  • Humans
  • African Americans
  • Aged
  • Genome-Wide Association Study
  • Validation Studies as Topic
  • Genotype
  • Adult
  • Cohort Studies
  • Diabetes Mellitus, Type 2
  • Case-Control Studies
  • Middle Aged
  • Genetic Predisposition to Disease
  • Meta-Analysis as Topic
  • Female
  • Male

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