A genome-wide association search for type 2 diabetes genes in African Americans

Nicholette D Palmer; Caitrin W McDonough; Pamela J Hicks; Bong H Roh; Maria R Wing; S Sandy An; Jessica M Hester; Jessica N Cooke; Meredith A Bostrom; Megan E Rudock; Matthew E Talbert; Joshua P Lewis; Assiamira Ferrara; Lingyi Lu; Julie T Ziegler; Michele M Sale; Jasmin Divers; Daniel Shriner; Adebowale Adeyemo; Charles N Rotimi; Maggie C Y Ng; Carl D Langefeld; Barry I Freedman; Donald W Bowden; Benjamin F Voight; Laura J Scott; Valgerdur Steinthorsdottir; Andrew P Morris; Christian Dina; Ryan P Welch; Eleftheria Zeggini; Cornelia Huth; Yurii S Aulchenko; Gudmar Thorleifsson; Laura J McCulloch; Teresa Ferreira; Harald Grallert; Najaf Amin; Guanming Wu; Cristen J Willer; Paul R V Johnson; Meena Kumari; Nicholas J Timpson; Yoav Ben-Shlomo; Ian N M Day; Mika Kivimaki; Debbie A Lawlor; George Davey Smith; Lyle J Palmer; Shah Ebrahim; DIAGRAM Consortium

doi:10.1371/journal.pone.0029202

A genome-wide association search for type 2 diabetes genes in African Americans

Nicholette D Palmer, Caitrin W McDonough, Pamela J Hicks, Bong H Roh, Maria R Wing, S Sandy An, Jessica M Hester, Jessica N Cooke, Meredith A Bostrom, Megan E Rudock, Matthew E Talbert, Joshua P Lewis, Assiamira Ferrara, Lingyi Lu, Julie T Ziegler, Michele M Sale, Jasmin Divers, Daniel Shriner, Adebowale Adeyemo, Charles N RotimiMaggie C Y Ng, Carl D Langefeld, Barry I Freedman, Donald W Bowden, Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, Ryan P Welch, Eleftheria Zeggini, Cornelia Huth, Yurii S Aulchenko, Gudmar Thorleifsson, Laura J McCulloch, Teresa Ferreira, Harald Grallert, Najaf Amin, Guanming Wu, Cristen J Willer, Paul R V Johnson, Meena Kumari, Nicholas J Timpson, Yoav Ben-Shlomo, Ian N M Day, Mika Kivimaki, Debbie A Lawlor, George Davey Smith, Lyle J Palmer, Shah Ebrahim, DIAGRAM Consortium

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Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

Original language	English
Pages (from-to)	e29202
Journal	PLoS ONE
Volume	7
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0029202
Publication status	Published - 2012

Keywords

Polymorphism, Single Nucleotide
Humans
African Americans
Aged
Genome-Wide Association Study
Validation Studies as Topic
Genotype
Adult
Cohort Studies
Diabetes Mellitus, Type 2
Case-Control Studies
Middle Aged
Genetic Predisposition to Disease
Meta-Analysis as Topic
Female
Male

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., ... DIAGRAM Consortium (2012). A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE, 7(1), e29202. https://doi.org/10.1371/journal.pone.0029202

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abstract = "African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P",

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author = "Palmer, {Nicholette D} and McDonough, {Caitrin W} and Hicks, {Pamela J} and Roh, {Bong H} and Wing, {Maria R} and An, {S Sandy} and Hester, {Jessica M} and Cooke, {Jessica N} and Bostrom, {Meredith A} and Rudock, {Megan E} and Talbert, {Matthew E} and Lewis, {Joshua P} and Assiamira Ferrara and Lingyi Lu and Ziegler, {Julie T} and Sale, {Michele M} and Jasmin Divers and Daniel Shriner and Adebowale Adeyemo and Rotimi, {Charles N} and Ng, {Maggie C Y} and Langefeld, {Carl D} and Freedman, {Barry I} and Bowden, {Donald W} and Voight, {Benjamin F} and Scott, {Laura J} and Valgerdur Steinthorsdottir and Morris, {Andrew P} and Christian Dina and Welch, {Ryan P} and Eleftheria Zeggini and Cornelia Huth and Aulchenko, {Yurii S} and Gudmar Thorleifsson and McCulloch, {Laura J} and Teresa Ferreira and Harald Grallert and Najaf Amin and Guanming Wu and Willer, {Cristen J} and Johnson, {Paul R V} and Meena Kumari and Timpson, {Nicholas J} and Yoav Ben-Shlomo and Day, {Ian N M} and Mika Kivimaki and Lawlor, {Debbie A} and Smith, {George Davey} and Palmer, {Lyle J} and Shah Ebrahim and {DIAGRAM Consortium}",

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doi = "10.1371/journal.pone.0029202",

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issn = "1932-6203",

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Palmer, ND, McDonough, CW, Hicks, PJ, Roh, BH, Wing, MR, An, SS, Hester, JM, Cooke, JN, Bostrom, MA, Rudock, ME, Talbert, ME, Lewis, JP, Ferrara, A, Lu, L, Ziegler, JT, Sale, MM, Divers, J, Shriner, D, Adeyemo, A, Rotimi, CN, Ng, MCY, Langefeld, CD, Freedman, BI, Bowden, DW, Voight, BF, Scott, LJ, Steinthorsdottir, V, Morris, AP, Dina, C, Welch, RP, Zeggini, E, Huth, C, Aulchenko, YS, Thorleifsson, G, McCulloch, LJ, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, CJ, Johnson, PRV, Kumari, M, Timpson, NJ , Ben-Shlomo, Y, Day, INM, Kivimaki, M, Lawlor, DA , Smith, GD, Palmer, LJ, Ebrahim, S & DIAGRAM Consortium 2012, 'A genome-wide association search for type 2 diabetes genes in African Americans', PLoS ONE, vol. 7, no. 1, pp. e29202. https://doi.org/10.1371/journal.pone.0029202

TY - JOUR

T1 - A genome-wide association search for type 2 diabetes genes in African Americans

AU - Palmer, Nicholette D

AU - McDonough, Caitrin W

AU - Hicks, Pamela J

AU - Roh, Bong H

AU - Wing, Maria R

AU - An, S Sandy

AU - Hester, Jessica M

AU - Cooke, Jessica N

AU - Bostrom, Meredith A

AU - Rudock, Megan E

AU - Talbert, Matthew E

AU - Lewis, Joshua P

AU - Ferrara, Assiamira

AU - Lu, Lingyi

AU - Ziegler, Julie T

AU - Sale, Michele M

AU - Divers, Jasmin

AU - Shriner, Daniel

AU - Adeyemo, Adebowale

AU - Rotimi, Charles N

AU - Ng, Maggie C Y

AU - Langefeld, Carl D

AU - Freedman, Barry I

AU - Bowden, Donald W

AU - Voight, Benjamin F

AU - Scott, Laura J

AU - Steinthorsdottir, Valgerdur

AU - Morris, Andrew P

AU - Dina, Christian

AU - Welch, Ryan P

AU - Zeggini, Eleftheria

AU - Huth, Cornelia

AU - Aulchenko, Yurii S

AU - Thorleifsson, Gudmar

AU - McCulloch, Laura J

AU - Ferreira, Teresa

AU - Grallert, Harald

AU - Amin, Najaf

AU - Wu, Guanming

AU - Willer, Cristen J

AU - Johnson, Paul R V

AU - Kumari, Meena

AU - Timpson, Nicholas J

AU - Ben-Shlomo, Yoav

AU - Day, Ian N M

AU - Kivimaki, Mika

AU - Lawlor, Debbie A

AU - Smith, George Davey

AU - Palmer, Lyle J

AU - Ebrahim, Shah

AU - DIAGRAM Consortium

PY - 2012

Y1 - 2012

N2 - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

AB - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

KW - Polymorphism, Single Nucleotide

KW - Humans

KW - African Americans

KW - Aged

KW - Genome-Wide Association Study

KW - Validation Studies as Topic

KW - Genotype

KW - Adult

KW - Cohort Studies

KW - Diabetes Mellitus, Type 2

KW - Case-Control Studies

KW - Middle Aged

KW - Genetic Predisposition to Disease

KW - Meta-Analysis as Topic

KW - Female

KW - Male

U2 - 10.1371/journal.pone.0029202

DO - 10.1371/journal.pone.0029202

M3 - Article (Academic Journal)

C2 - 22238593

SN - 1932-6203

VL - 7

SP - e29202

JO - PLoS ONE

JF - PLoS ONE

IS - 1

ER -

A genome-wide association search for type 2 diabetes genes in African Americans

Abstract

Keywords

UN SDGs

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