A genome-wide association search for type 2 diabetes genes in African Americans

Nicholette D Palmer; Caitrin W McDonough; Pamela J Hicks; Bong H Roh; Maria R Wing; S Sandy An; Jessica M Hester; Jessica N Cooke; Meredith A Bostrom; Megan E Rudock; Matthew E Talbert; Joshua P Lewis; Assiamira Ferrara; Lingyi Lu; Julie T Ziegler; Michele M Sale; Jasmin Divers; Daniel Shriner; Adebowale Adeyemo; Charles N Rotimi; Maggie C Y Ng; Carl D Langefeld; Barry I Freedman; Donald W Bowden; Benjamin F Voight; Laura J Scott; Valgerdur Steinthorsdottir; Andrew P Morris; Christian Dina; Ryan P Welch; Eleftheria Zeggini; Cornelia Huth; Yurii S Aulchenko; Gudmar Thorleifsson; Laura J McCulloch; Teresa Ferreira; Harald Grallert; Najaf Amin; Guanming Wu; Cristen J Willer; Paul R V Johnson; Meena Kumari; Nicholas J Timpson; Yoav Ben-Shlomo; Ian N M Day; Mika Kivimaki; Debbie A Lawlor; George Davey Smith; Lyle J Palmer; Shah Ebrahim; DIAGRAM Consortium

doi:10.1371/journal.pone.0029202

A genome-wide association search for type 2 diabetes genes in African Americans

Nicholette D Palmer
, Caitrin W McDonough
, Pamela J Hicks
, Bong H Roh
, Maria R Wing
, S Sandy An
, Jessica M Hester
, Jessica N Cooke
, Meredith A Bostrom
, Megan E Rudock
, Matthew E Talbert
, Joshua P Lewis
, Assiamira Ferrara
, Lingyi Lu
, Julie T Ziegler
, Michele M Sale
, Jasmin Divers
, Daniel Shriner
, Adebowale Adeyemo
, Charles N Rotimi

Maggie C Y Ng, Carl D Langefeld, Barry I Freedman, Donald W Bowden, Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, Ryan P Welch, Eleftheria Zeggini, Cornelia Huth, Yurii S Aulchenko, Gudmar Thorleifsson, Laura J McCulloch, Teresa Ferreira, Harald Grallert, Najaf Amin, Guanming Wu, Cristen J Willer, Paul R V Johnson, Meena Kumari, Nicholas J Timpson, Yoav Ben-Shlomo, Ian N M Day, Mika Kivimaki, Debbie A Lawlor, George Davey Smith, Lyle J Palmer, Shah Ebrahim, DIAGRAM Consortium

Research output: Contribution to journal › Article (Academic Journal) › peer-review

151 Citations (Scopus)

Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

Original language	English
Pages (from-to)	e29202
Journal	PLOS ONE
Volume	7
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0029202
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Polymorphism, Single Nucleotide
Humans
African Americans
Aged
Genome-Wide Association Study
Validation Studies as Topic
Genotype
Adult
Cohort Studies
Diabetes Mellitus, Type 2
Case-Control Studies
Middle Aged
Genetic Predisposition to Disease
Meta-Analysis as Topic
Female
Male

Access to Document

10.1371/journal.pone.0029202

Handle.net

Persistent link

Cite this

Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., ... DIAGRAM Consortium (2012). A genome-wide association search for type 2 diabetes genes in African Americans. PLOS ONE, 7(1), e29202. https://doi.org/10.1371/journal.pone.0029202

@article{17ae98dcf3574eb49322a843f510e32a,

title = "A genome-wide association search for type 2 diabetes genes in African Americans",

abstract = "African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P",

keywords = "Polymorphism, Single Nucleotide, Humans, African Americans, Aged, Genome-Wide Association Study, Validation Studies as Topic, Genotype, Adult, Cohort Studies, Diabetes Mellitus, Type 2, Case-Control Studies, Middle Aged, Genetic Predisposition to Disease, Meta-Analysis as Topic, Female, Male",

author = "Palmer, \{Nicholette D\} and McDonough, \{Caitrin W\} and Hicks, \{Pamela J\} and Roh, \{Bong H\} and Wing, \{Maria R\} and An, \{S Sandy\} and Hester, \{Jessica M\} and Cooke, \{Jessica N\} and Bostrom, \{Meredith A\} and Rudock, \{Megan E\} and Talbert, \{Matthew E\} and Lewis, \{Joshua P\} and Assiamira Ferrara and Lingyi Lu and Ziegler, \{Julie T\} and Sale, \{Michele M\} and Jasmin Divers and Daniel Shriner and Adebowale Adeyemo and Rotimi, \{Charles N\} and Ng, \{Maggie C Y\} and Langefeld, \{Carl D\} and Freedman, \{Barry I\} and Bowden, \{Donald W\} and Voight, \{Benjamin F\} and Scott, \{Laura J\} and Valgerdur Steinthorsdottir and Morris, \{Andrew P\} and Christian Dina and Welch, \{Ryan P\} and Eleftheria Zeggini and Cornelia Huth and Aulchenko, \{Yurii S\} and Gudmar Thorleifsson and McCulloch, \{Laura J\} and Teresa Ferreira and Harald Grallert and Najaf Amin and Guanming Wu and Willer, \{Cristen J\} and Johnson, \{Paul R V\} and Meena Kumari and Timpson, \{Nicholas J\} and Yoav Ben-Shlomo and Day, \{Ian N M\} and Mika Kivimaki and Lawlor, \{Debbie A\} and Smith, \{George Davey\} and Palmer, \{Lyle J\} and Shah Ebrahim and \{DIAGRAM Consortium\}",

year = "2012",

doi = "10.1371/journal.pone.0029202",

language = "English",

volume = "7",

pages = "e29202",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "1",

}

Palmer, ND, McDonough, CW, Hicks, PJ, Roh, BH, Wing, MR, An, SS, Hester, JM, Cooke, JN, Bostrom, MA, Rudock, ME, Talbert, ME, Lewis, JP, Ferrara, A, Lu, L, Ziegler, JT, Sale, MM, Divers, J, Shriner, D, Adeyemo, A, Rotimi, CN, Ng, MCY, Langefeld, CD, Freedman, BI, Bowden, DW, Voight, BF, Scott, LJ, Steinthorsdottir, V, Morris, AP, Dina, C, Welch, RP, Zeggini, E, Huth, C, Aulchenko, YS, Thorleifsson, G, McCulloch, LJ, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, CJ, Johnson, PRV, Kumari, M, Timpson, NJ, Ben-Shlomo, Y, Day, INM, Kivimaki, M, Lawlor, DA , Smith, GD, Palmer, LJ, Ebrahim, S & DIAGRAM Consortium 2012, 'A genome-wide association search for type 2 diabetes genes in African Americans', PLOS ONE, vol. 7, no. 1, pp. e29202. https://doi.org/10.1371/journal.pone.0029202

TY - JOUR

T1 - A genome-wide association search for type 2 diabetes genes in African Americans

AU - Palmer, Nicholette D

AU - McDonough, Caitrin W

AU - Hicks, Pamela J

AU - Roh, Bong H

AU - Wing, Maria R

AU - An, S Sandy

AU - Hester, Jessica M

AU - Cooke, Jessica N

AU - Bostrom, Meredith A

AU - Rudock, Megan E

AU - Talbert, Matthew E

AU - Lewis, Joshua P

AU - Ferrara, Assiamira

AU - Lu, Lingyi

AU - Ziegler, Julie T

AU - Sale, Michele M

AU - Divers, Jasmin

AU - Shriner, Daniel

AU - Adeyemo, Adebowale

AU - Rotimi, Charles N

AU - Ng, Maggie C Y

AU - Langefeld, Carl D

AU - Freedman, Barry I

AU - Bowden, Donald W

AU - Voight, Benjamin F

AU - Scott, Laura J

AU - Steinthorsdottir, Valgerdur

AU - Morris, Andrew P

AU - Dina, Christian

AU - Welch, Ryan P

AU - Zeggini, Eleftheria

AU - Huth, Cornelia

AU - Aulchenko, Yurii S

AU - Thorleifsson, Gudmar

AU - McCulloch, Laura J

AU - Ferreira, Teresa

AU - Grallert, Harald

AU - Amin, Najaf

AU - Wu, Guanming

AU - Willer, Cristen J

AU - Johnson, Paul R V

AU - Kumari, Meena

AU - Timpson, Nicholas J

AU - Ben-Shlomo, Yoav

AU - Day, Ian N M

AU - Kivimaki, Mika

AU - Lawlor, Debbie A

AU - Smith, George Davey

AU - Palmer, Lyle J

AU - Ebrahim, Shah

AU - DIAGRAM Consortium

PY - 2012

Y1 - 2012

N2 - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

AB - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

KW - Polymorphism, Single Nucleotide

KW - Humans

KW - African Americans

KW - Aged

KW - Genome-Wide Association Study

KW - Validation Studies as Topic

KW - Genotype

KW - Adult

KW - Cohort Studies

KW - Diabetes Mellitus, Type 2

KW - Case-Control Studies

KW - Middle Aged

KW - Genetic Predisposition to Disease

KW - Meta-Analysis as Topic

KW - Female

KW - Male

U2 - 10.1371/journal.pone.0029202

DO - 10.1371/journal.pone.0029202

M3 - Article (Academic Journal)

C2 - 22238593

SN - 1932-6203

VL - 7

SP - e29202

JO - PLOS ONE

JF - PLOS ONE

IS - 1

ER -

A genome-wide association search for type 2 diabetes genes in African Americans

Abstract

UN SDGs

Keywords

Access to Document

Handle.net

Fingerprint

Cite this