A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order

Adaikalavan Ramasamy, Ivan Curjuric, Lachlan J Coin, Ashish Kumar, Wendy L McArdle, Medea Imboden, Benedicte Leynaert, Manolis Kogevinas, Peter Schmid-Grendelmeier, Juha Pekkanen, Matthias Wjst, Andreas J Bircher, Ulla Sovio, Thierry Rochat, Anna-Liisa Hartikainen, David J Balding, Marjo-Riitta Jarvelin, Nicole Probst-Hensch, David P Strachan, Deborah L Jarvis

Research output: Contribution to journalArticle (Academic Journal)

151 Citations (Scopus)

Abstract

Hay fever or seasonal allergic rhinitis (AR) is a chronic disorder associated with IgE sensitization to grass. The underlying genetic variants have not been studied comprehensively. There is overwhelming evidence that those who have older siblings have less AR, although the mechanism for this remains unclear.
Original languageEnglish
Pages (from-to)996-1005
Number of pages10
JournalJournal of Allergy and Clinical Immunology
Volume128
Issue number5
DOIs
Publication statusPublished - 2011

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