A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order

Adaikalavan Ramasamy; Ivan Curjuric; Lachlan J Coin; Ashish Kumar; Wendy L McArdle; Medea Imboden; Benedicte Leynaert; Manolis Kogevinas; Peter Schmid-Grendelmeier; Juha Pekkanen; Matthias Wjst; Andreas J Bircher; Ulla Sovio; Thierry Rochat; Anna-Liisa Hartikainen; David J Balding; Marjo-Riitta Jarvelin; Nicole Probst-Hensch; David P Strachan; Deborah L Jarvis

doi:10.1016/j.jaci.2011.08.030

A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order

Adaikalavan Ramasamy, Ivan Curjuric, Lachlan J Coin, Ashish Kumar, Wendy L McArdle, Medea Imboden, Benedicte Leynaert, Manolis Kogevinas, Peter Schmid-Grendelmeier, Juha Pekkanen, Matthias Wjst, Andreas J Bircher, Ulla Sovio, Thierry Rochat, Anna-Liisa Hartikainen, David J Balding, Marjo-Riitta Jarvelin, Nicole Probst-Hensch, David P Strachan, Deborah L Jarvis

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

174 Citations (Scopus)

Abstract

Hay fever or seasonal allergic rhinitis (AR) is a chronic disorder associated with IgE sensitization to grass. The underlying genetic variants have not been studied comprehensively. There is overwhelming evidence that those who have older siblings have less AR, although the mechanism for this remains unclear.

Original language	English
Pages (from-to)	996-1005
Number of pages	10
Journal	Journal of Allergy and Clinical Immunology
Volume	128
Issue number	5
DOIs	https://doi.org/10.1016/j.jaci.2011.08.030
Publication status	Published - 2011

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Ramasamy, A., Curjuric, I., Coin, L. J., Kumar, A., McArdle, W. L., Imboden, M., Leynaert, B., Kogevinas, M., Schmid-Grendelmeier, P., Pekkanen, J., Wjst, M., Bircher, A. J., Sovio, U., Rochat, T., Hartikainen, A-L., Balding, D. J., Jarvelin, M-R., Probst-Hensch, N., Strachan, D. P., & Jarvis, D. L. (2011). A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. Journal of Allergy and Clinical Immunology, 128(5), 996-1005. https://doi.org/10.1016/j.jaci.2011.08.030

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title = "A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order",

abstract = "Hay fever or seasonal allergic rhinitis (AR) is a chronic disorder associated with IgE sensitization to grass. The underlying genetic variants have not been studied comprehensively. There is overwhelming evidence that those who have older siblings have less AR, although the mechanism for this remains unclear.",

author = "Adaikalavan Ramasamy and Ivan Curjuric and Coin, {Lachlan J} and Ashish Kumar and McArdle, {Wendy L} and Medea Imboden and Benedicte Leynaert and Manolis Kogevinas and Peter Schmid-Grendelmeier and Juha Pekkanen and Matthias Wjst and Bircher, {Andreas J} and Ulla Sovio and Thierry Rochat and Anna-Liisa Hartikainen and Balding, {David J} and Marjo-Riitta Jarvelin and Nicole Probst-Hensch and Strachan, {David P} and Jarvis, {Deborah L}",

year = "2011",

doi = "10.1016/j.jaci.2011.08.030",

language = "English",

volume = "128",

pages = "996--1005",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Elsevier Inc.",

number = "5",

}

Ramasamy, A, Curjuric, I, Coin, LJ, Kumar, A, McArdle, WL, Imboden, M, Leynaert, B, Kogevinas, M, Schmid-Grendelmeier, P, Pekkanen, J, Wjst, M, Bircher, AJ, Sovio, U, Rochat, T, Hartikainen, A-L, Balding, DJ, Jarvelin, M-R, Probst-Hensch, N, Strachan, DP & Jarvis, DL 2011, 'A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order', Journal of Allergy and Clinical Immunology, vol. 128, no. 5, pp. 996-1005. https://doi.org/10.1016/j.jaci.2011.08.030

A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. / Ramasamy, Adaikalavan; Curjuric, Ivan; Coin, Lachlan J et al.

In: Journal of Allergy and Clinical Immunology, Vol. 128, No. 5, 2011, p. 996-1005.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order

AU - Ramasamy, Adaikalavan

AU - Curjuric, Ivan

AU - Coin, Lachlan J

AU - Kumar, Ashish

AU - McArdle, Wendy L

AU - Imboden, Medea

AU - Leynaert, Benedicte

AU - Kogevinas, Manolis

AU - Schmid-Grendelmeier, Peter

AU - Pekkanen, Juha

AU - Wjst, Matthias

AU - Bircher, Andreas J

AU - Sovio, Ulla

AU - Rochat, Thierry

AU - Hartikainen, Anna-Liisa

AU - Balding, David J

AU - Jarvelin, Marjo-Riitta

AU - Probst-Hensch, Nicole

AU - Strachan, David P

AU - Jarvis, Deborah L

PY - 2011

Y1 - 2011

N2 - Hay fever or seasonal allergic rhinitis (AR) is a chronic disorder associated with IgE sensitization to grass. The underlying genetic variants have not been studied comprehensively. There is overwhelming evidence that those who have older siblings have less AR, although the mechanism for this remains unclear.

AB - Hay fever or seasonal allergic rhinitis (AR) is a chronic disorder associated with IgE sensitization to grass. The underlying genetic variants have not been studied comprehensively. There is overwhelming evidence that those who have older siblings have less AR, although the mechanism for this remains unclear.

U2 - 10.1016/j.jaci.2011.08.030

DO - 10.1016/j.jaci.2011.08.030

M3 - Article (Academic Journal)

C2 - 22036096

VL - 128

SP - 996

EP - 1005

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5

ER -

A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order

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