A High Input Impedance Low Noise Integrated Front-End Amplifier for Neural Monitoring

Zhijun Zhou; Paul A Warr

doi:10.1109/TBCAS.2016.2525810

A High Input Impedance Low Noise Integrated Front-End Amplifier for Neural Monitoring

Zhijun Zhou, Paul A Warr

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Abstract

Within neural monitoring systems, the front-end amplifier forms the critical element for signal detection and preprocessing, which determines not only the fidelity of the biosignal, but also impacts power consumption and detector size. In this paper, a novel combined feedback loop-controlled approach is proposed to compensate for input leakage currents generated by low noise amplifiers when in integrated circuit form alongside signal leakage into the input bias network. This loop topology ensures the FEA maintains a high input impedance across all manufacturing and operational variations. Measured results from a prototype manufactured on the AMS 0.35μm CMOS technology is provided. This FEA consumes 3.1 μW in 0.042 mm2, achieves input impedance of 42 GΩ, and 18.2 nv/√Hz input-referred noise.

Original language	English
Pages (from-to)	1079-1086
Number of pages	8
Journal	IEEE Transactions on Biomedical Circuits and Systems
Volume	10
Issue number	6
Early online date	23 May 2016
DOIs	https://doi.org/10.1109/TBCAS.2016.2525810
Publication status	Published - Dec 2016

Keywords

Neural recording
analogue integrated circuits
CMOS technology
biomedical signal processing
low-noise amplifiers

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10.1109/TBCAS.2016.2525810

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Dr Paul A Warr
- Paul.A.Warrbristol.acuk
- School of Electrical, Electronic and Mechanical Engineering - Senior Lecturer
- Communication Systems and Networks
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Cite this

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title = "A High Input Impedance Low Noise Integrated Front-End Amplifier for Neural Monitoring",

abstract = "Within neural monitoring systems, the front-end amplifier forms the critical element for signal detection and preprocessing, which determines not only the fidelity of the biosignal, but also impacts power consumption and detector size. In this paper, a novel combined feedback loop-controlled approach is proposed to compensate for input leakage currents generated by low noise amplifiers when in integrated circuit form alongside signal leakage into the input bias network. This loop topology ensures the FEA maintains a high input impedance across all manufacturing and operational variations. Measured results from a prototype manufactured on the AMS 0.35μm CMOS technology is provided. This FEA consumes 3.1 μW in 0.042 mm2, achieves input impedance of 42 GΩ, and 18.2 nv/√Hz input-referred noise.",

keywords = "Neural recording, analogue integrated circuits, CMOS technology, biomedical signal processing, low-noise amplifiers",

author = "Zhijun Zhou and Warr, \{Paul A\}",

year = "2016",

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T1 - A High Input Impedance Low Noise Integrated Front-End Amplifier for Neural Monitoring

AU - Zhou, Zhijun

AU - Warr, Paul A

PY - 2016/12

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N2 - Within neural monitoring systems, the front-end amplifier forms the critical element for signal detection and preprocessing, which determines not only the fidelity of the biosignal, but also impacts power consumption and detector size. In this paper, a novel combined feedback loop-controlled approach is proposed to compensate for input leakage currents generated by low noise amplifiers when in integrated circuit form alongside signal leakage into the input bias network. This loop topology ensures the FEA maintains a high input impedance across all manufacturing and operational variations. Measured results from a prototype manufactured on the AMS 0.35μm CMOS technology is provided. This FEA consumes 3.1 μW in 0.042 mm2, achieves input impedance of 42 GΩ, and 18.2 nv/√Hz input-referred noise.

AB - Within neural monitoring systems, the front-end amplifier forms the critical element for signal detection and preprocessing, which determines not only the fidelity of the biosignal, but also impacts power consumption and detector size. In this paper, a novel combined feedback loop-controlled approach is proposed to compensate for input leakage currents generated by low noise amplifiers when in integrated circuit form alongside signal leakage into the input bias network. This loop topology ensures the FEA maintains a high input impedance across all manufacturing and operational variations. Measured results from a prototype manufactured on the AMS 0.35μm CMOS technology is provided. This FEA consumes 3.1 μW in 0.042 mm2, achieves input impedance of 42 GΩ, and 18.2 nv/√Hz input-referred noise.

KW - Neural recording

KW - analogue integrated circuits

KW - CMOS technology

KW - biomedical signal processing

KW - low-noise amplifiers

U2 - 10.1109/TBCAS.2016.2525810

DO - 10.1109/TBCAS.2016.2525810

M3 - Article (Academic Journal)

C2 - 27244748

SN - 1932-4545

VL - 10

SP - 1079

EP - 1086

JO - IEEE Transactions on Biomedical Circuits and Systems

JF - IEEE Transactions on Biomedical Circuits and Systems

IS - 6

ER -

A High Input Impedance Low Noise Integrated Front-End Amplifier for Neural Monitoring

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