A hybrid atomistic approach for the mechanics of deoxyribonucleic acid molecules

S. Adhikari, E. I. Saavedra Flores, F. Scarpa, R. Chowdhury, M. I. Friswell

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Abstract

The paper proposes a new modeling approach for the prediction and analysis of the mechanical properties in deoxyribonucleic acid (DNA) molecules based on a hybrid atomistic-finite element continuum representation. The model takes into account of the complex geometry of the DNA strands, a structural mechanics representation of the atomic bonds existing in the molecules and the mass distribution of the atoms by using a lumped parameter model. A 13-base-pair DNA model is used to illustrate the proposed approach. The properties of the equivalent bond elements used to represent the DNA model have been derived. The natural frequencies, vibration mode shapes, and equivalent continuum mechanical properties of the DNA strand are obtained. The results from our model compare well with a high-fidelity molecular mechanics simulation and existing MD and experimental data from open literature.

Original languageEnglish
Article number041006
JournalJournal of Nanotechnology in Engineering and Medicine
Volume4
Issue number4
DOIs
Publication statusPublished - 1 Jan 2013

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