A large-scale, consortium-based genomewide association study of asthma

Miriam F Moffatt, Ivo G Gut, Florence Demenais, David P Strachan, Emmanuelle Bouzigon, Simon Heath, Erika von Mutius, Martin Farrall, Mark Lathrop, William O C M Cookson, GABRIEL Consortium, Wendy L McArdle

Research output: Contribution to journalArticle (Academic Journal)peer-review

1335 Citations (Scopus)

Abstract

Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease.
Original languageEnglish
Pages (from-to)1211-21
Number of pages11
JournalNew England Journal of Medicine
Volume363
Issue number13
DOIs
Publication statusPublished - 2010

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