A large-scale, consortium-based genomewide association study of asthma

Miriam F Moffatt; Ivo G Gut; Florence Demenais; David P Strachan; Emmanuelle Bouzigon; Simon Heath; Erika von Mutius; Martin Farrall; Mark Lathrop; William O C M Cookson; GABRIEL Consortium; Wendy L McArdle

doi:10.1056/NEJMoa0906312

A large-scale, consortium-based genomewide association study of asthma

Miriam F Moffatt, Ivo G Gut, Florence Demenais, David P Strachan, Emmanuelle Bouzigon, Simon Heath, Erika von Mutius, Martin Farrall, Mark Lathrop, William O C M Cookson, GABRIEL Consortium, Wendy L McArdle

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

1661 Citations (Scopus)

Abstract

Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease.

Original language	English
Pages (from-to)	1211-21
Number of pages	11
Journal	New England Journal of Medicine
Volume	363
Issue number	13
DOIs	https://doi.org/10.1056/NEJMoa0906312
Publication status	Published - 2010

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THE NATURAL HISTORY OF ASTHMA AND WHEEZING ILLNESSES FROM BIRTH TO ADOLESCENCE: DETERMINANTS OF THE REMISSION OF ASTHMA
Henderson, A. J. W. (Principal Investigator)
1/10/06 → 1/10/10
Project: Research

Cite this

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title = "A large-scale, consortium-based genomewide association study of asthma",

abstract = "Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease.",

author = "Moffatt, {Miriam F} and Gut, {Ivo G} and Florence Demenais and Strachan, {David P} and Emmanuelle Bouzigon and Simon Heath and {von Mutius}, Erika and Martin Farrall and Mark Lathrop and Cookson, {William O C M} and {GABRIEL Consortium} and McArdle, {Wendy L}",

year = "2010",

doi = "10.1056/NEJMoa0906312",

language = "English",

volume = "363",

pages = "1211--21",

journal = "New England Journal of Medicine",

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AU - Moffatt, Miriam F

AU - Gut, Ivo G

AU - Demenais, Florence

AU - Strachan, David P

AU - Bouzigon, Emmanuelle

AU - Heath, Simon

AU - von Mutius, Erika

AU - Farrall, Martin

AU - Lathrop, Mark

AU - Cookson, William O C M

AU - GABRIEL Consortium

AU - McArdle, Wendy L

PY - 2010

Y1 - 2010

N2 - Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease.

AB - Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease.

U2 - 10.1056/NEJMoa0906312

DO - 10.1056/NEJMoa0906312

M3 - Article (Academic Journal)

C2 - 20860503

SN - 0028-4793

VL - 363

SP - 1211

EP - 1221

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 13

ER -

A large-scale, consortium-based genomewide association study of asthma

Abstract

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THE NATURAL HISTORY OF ASTHMA AND WHEEZING ILLNESSES FROM BIRTH TO ADOLESCENCE: DETERMINANTS OF THE REMISSION OF ASTHMA

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