A marginalized variational Bayesian approach to the analysis of array data

Yiming Ying, Peng Li, I C G Campbell

Research output: Contribution to journalArticle (Academic Journal)

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Abstract

Background

Bayesian unsupervised learning methods have many applications in the analysis of biological data. For example, for the cancer expression array datasets presented in this study, they can be used to resolve possible disease subtypes and to indicate statistically significant dysregulated genes within these subtypes.

Results

In this paper we outline a marginalized variational Bayesian inference method for unsupervised clustering. In this approach latent process variables and model parameters are allowed to be dependent. This is achieved by marginalizing the mixing Dirichlet variables and then performing inference in the reduced variable space. An iterative update procedure is proposed.

Conclusion

Theoretically and experimentally we show that the proposed algorithm gives a much better free-energy lower bound than a standard variational Bayesian approach. The algorithm is computationally efficient and its performance is demonstrated on two expression array data sets.
Translated title of the contributionA marginalized variational Bayesian approach to the analysis of array data
Original languageEnglish
Article number57
Number of pages7
JournalBMC Proceedings
Volume2 (Suppl 4)
DOIs
Publication statusPublished - 17 Dec 2008

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