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A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density

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A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density. / Kemp, John P.; Sayers, Adrian; Fraser, William D.; Davey Smith, George; Ala-Korpela, Mika; Evans, David M.; Tobias, Jonathan H.

In: Journal of Bone and Mineral Research, Vol. 34, No. 7, e3697, 01.07.2019, p. 1306-1313.

Research output: Contribution to journalArticle

Harvard

Kemp, JP, Sayers, A, Fraser, WD, Davey Smith, G, Ala-Korpela, M, Evans, DM & Tobias, JH 2019, 'A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density', Journal of Bone and Mineral Research, vol. 34, no. 7, e3697, pp. 1306-1313. https://doi.org/10.1002/jbmr.3697

APA

Kemp, J. P., Sayers, A., Fraser, W. D., Davey Smith, G., Ala-Korpela, M., Evans, D. M., & Tobias, J. H. (2019). A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density. Journal of Bone and Mineral Research, 34(7), 1306-1313. [e3697]. https://doi.org/10.1002/jbmr.3697

Vancouver

Kemp JP, Sayers A, Fraser WD, Davey Smith G, Ala-Korpela M, Evans DM et al. A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density. Journal of Bone and Mineral Research. 2019 Jul 1;34(7):1306-1313. e3697. https://doi.org/10.1002/jbmr.3697

Author

Kemp, John P. ; Sayers, Adrian ; Fraser, William D. ; Davey Smith, George ; Ala-Korpela, Mika ; Evans, David M. ; Tobias, Jonathan H. / A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density. In: Journal of Bone and Mineral Research. 2019 ; Vol. 34, No. 7. pp. 1306-1313.

Bibtex

@article{7ca3766e9fee4c589f384a0f63c2323a,
title = "A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density",
abstract = "Observations that insulin and adiponectin levels are related to cortical bone size in adolescents, independently of body composition, suggest factors related to fat metabolism directly influence skeletal development. To explore this question, we examined associations between a metabolic screen focusing on fat metabolism, and peripheral quantitative computed tomography (pQCT) measures of the mid-tibia, in 15-year-olds from the Avon Longitudinal Study of Parents and Children. Metabolic profiles were generated by proton nuclear magnetic resonance spectroscopy, from blood samples obtained at the same time as pQCT scans. Ordinary least squares linear regression was used to investigate relationships between metabolic measures and periosteal circumference (PC), cortical thickness (CT), and cortical bone mineral density (BMDC). Metabolic profiles yielded 22 independent components following principal component analysis (PCA), giving a Bonferroni-adjusted threshold for statistical significance of p = 0.002. Data were available in 1121 subjects (487 males), mean age 15 years. Several metabolites related to lipid and cholesterol metabolism were associated with PC, CT, and BMDC after adjustment for age, sex, and Tanner stage. After additional adjustment for height, fat, and lean mass, only the association between citrate and BMDC remained below the Bonferroni-significant threshold (β = –0.14 [–0.18, –0.09]) (β represents a standardized coefficient). Citrate also showed evidence of association with PC (β = 0.06 [0.03, 0.10]) and strength strain index (SSI; β = 0.04 [0.01, 0.08]). Subsequently, we investigated whether these relationships were explained by increased bone resorption. Citrate was strongly related to serum β-C-telopeptides of type I collagen (β-CTX) (β = 0.20 [0.16, 0.23]). After additional adjustment for β-CTX the above associations between citrate and BMDC (β = –0.04 [–0.08, 0.01]), PC (β = 0.03 [–0.01, 0.07]) and SSI (β = 0.03 [–0.01, 0.07]) were no longer observed. We conclude that in adolescents, circulating levels of citrate are inversely related to BMDC and positively related to PC, reflecting associations with higher bone turnover. Further studies are justified to elucidate possible contributions of citrate, a constituent of bone matrix, to bone resorption and cortical density.",
keywords = "pQCT, Bone Resorption, β-CTX, lipids, ALSPAC",
author = "Kemp, {John P.} and Adrian Sayers and Fraser, {William D.} and {Davey Smith}, George and Mika Ala-Korpela and Evans, {David M.} and Tobias, {Jonathan H.}",
year = "2019",
month = "7",
day = "1",
doi = "10.1002/jbmr.3697",
language = "English",
volume = "34",
pages = "1306--1313",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley",
number = "7",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density

AU - Kemp, John P.

AU - Sayers, Adrian

AU - Fraser, William D.

AU - Davey Smith, George

AU - Ala-Korpela, Mika

AU - Evans, David M.

AU - Tobias, Jonathan H.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Observations that insulin and adiponectin levels are related to cortical bone size in adolescents, independently of body composition, suggest factors related to fat metabolism directly influence skeletal development. To explore this question, we examined associations between a metabolic screen focusing on fat metabolism, and peripheral quantitative computed tomography (pQCT) measures of the mid-tibia, in 15-year-olds from the Avon Longitudinal Study of Parents and Children. Metabolic profiles were generated by proton nuclear magnetic resonance spectroscopy, from blood samples obtained at the same time as pQCT scans. Ordinary least squares linear regression was used to investigate relationships between metabolic measures and periosteal circumference (PC), cortical thickness (CT), and cortical bone mineral density (BMDC). Metabolic profiles yielded 22 independent components following principal component analysis (PCA), giving a Bonferroni-adjusted threshold for statistical significance of p = 0.002. Data were available in 1121 subjects (487 males), mean age 15 years. Several metabolites related to lipid and cholesterol metabolism were associated with PC, CT, and BMDC after adjustment for age, sex, and Tanner stage. After additional adjustment for height, fat, and lean mass, only the association between citrate and BMDC remained below the Bonferroni-significant threshold (β = –0.14 [–0.18, –0.09]) (β represents a standardized coefficient). Citrate also showed evidence of association with PC (β = 0.06 [0.03, 0.10]) and strength strain index (SSI; β = 0.04 [0.01, 0.08]). Subsequently, we investigated whether these relationships were explained by increased bone resorption. Citrate was strongly related to serum β-C-telopeptides of type I collagen (β-CTX) (β = 0.20 [0.16, 0.23]). After additional adjustment for β-CTX the above associations between citrate and BMDC (β = –0.04 [–0.08, 0.01]), PC (β = 0.03 [–0.01, 0.07]) and SSI (β = 0.03 [–0.01, 0.07]) were no longer observed. We conclude that in adolescents, circulating levels of citrate are inversely related to BMDC and positively related to PC, reflecting associations with higher bone turnover. Further studies are justified to elucidate possible contributions of citrate, a constituent of bone matrix, to bone resorption and cortical density.

AB - Observations that insulin and adiponectin levels are related to cortical bone size in adolescents, independently of body composition, suggest factors related to fat metabolism directly influence skeletal development. To explore this question, we examined associations between a metabolic screen focusing on fat metabolism, and peripheral quantitative computed tomography (pQCT) measures of the mid-tibia, in 15-year-olds from the Avon Longitudinal Study of Parents and Children. Metabolic profiles were generated by proton nuclear magnetic resonance spectroscopy, from blood samples obtained at the same time as pQCT scans. Ordinary least squares linear regression was used to investigate relationships between metabolic measures and periosteal circumference (PC), cortical thickness (CT), and cortical bone mineral density (BMDC). Metabolic profiles yielded 22 independent components following principal component analysis (PCA), giving a Bonferroni-adjusted threshold for statistical significance of p = 0.002. Data were available in 1121 subjects (487 males), mean age 15 years. Several metabolites related to lipid and cholesterol metabolism were associated with PC, CT, and BMDC after adjustment for age, sex, and Tanner stage. After additional adjustment for height, fat, and lean mass, only the association between citrate and BMDC remained below the Bonferroni-significant threshold (β = –0.14 [–0.18, –0.09]) (β represents a standardized coefficient). Citrate also showed evidence of association with PC (β = 0.06 [0.03, 0.10]) and strength strain index (SSI; β = 0.04 [0.01, 0.08]). Subsequently, we investigated whether these relationships were explained by increased bone resorption. Citrate was strongly related to serum β-C-telopeptides of type I collagen (β-CTX) (β = 0.20 [0.16, 0.23]). After additional adjustment for β-CTX the above associations between citrate and BMDC (β = –0.04 [–0.08, 0.01]), PC (β = 0.03 [–0.01, 0.07]) and SSI (β = 0.03 [–0.01, 0.07]) were no longer observed. We conclude that in adolescents, circulating levels of citrate are inversely related to BMDC and positively related to PC, reflecting associations with higher bone turnover. Further studies are justified to elucidate possible contributions of citrate, a constituent of bone matrix, to bone resorption and cortical density.

KW - pQCT

KW - Bone Resorption

KW - β-CTX

KW - lipids

KW - ALSPAC

UR - http://www.scopus.com/inward/record.url?scp=85069761030&partnerID=8YFLogxK

U2 - 10.1002/jbmr.3697

DO - 10.1002/jbmr.3697

M3 - Article

C2 - 30882941

AN - SCOPUS:85069761030

VL - 34

SP - 1306

EP - 1313

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 7

M1 - e3697

ER -