A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

Edward D Barker*, Esther Walton, Charlotte A.M. Cecil, Richard Rowe, Sara R. Jaffee, Barbara Maughan, Thomas G. O'Connor, Argyris Stringaris, Alan J. Meehan, Wendy McArdle, Caroline L. Relton, Tom R. Gaunt

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

6 Citations (Scopus)
237 Downloads (Pure)

Abstract

In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).

Original languageEnglish
Pages (from-to)1839-1855
Number of pages17
JournalChild Development
Volume89
Issue number5
Early online date20 Sep 2017
DOIs
Publication statusPublished - Sep 2018

Keywords

  • ALSPAC
  • Oppositional Defiant Disorder
  • Irritability
  • Headstrong
  • Attention Deficit Hyperactivity Disorder
  • DNA methylation

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