A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

Edward D Barker; Esther Walton; Charlotte A.M. Cecil; Richard Rowe; Sara R. Jaffee; Barbara Maughan; Thomas G. O'Connor; Argyris Stringaris; Alan J. Meehan; Wendy McArdle; Caroline L. Relton; Tom R. Gaunt

doi:10.1111/cdev.12957

A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

Edward D Barker^*, Esther Walton, Charlotte A.M. Cecil, Richard Rowe, Sara R. Jaffee, Barbara Maughan, Thomas G. O'Connor, Argyris Stringaris, Alan J. Meehan, Wendy McArdle, Caroline L. Relton, Tom R. Gaunt

^*Corresponding author for this work

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Abstract

In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).

Original language	English
Pages (from-to)	1839-1855
Number of pages	17
Journal	Child Development
Volume	89
Issue number	5
Early online date	20 Sept 2017
DOIs	https://doi.org/10.1111/cdev.12957
Publication status	Published - Sept 2018

Keywords

ALSPAC
Oppositional Defiant Disorder
Irritability
Headstrong
Attention Deficit Hyperactivity Disorder
DNA methylation

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10.1111/cdev.12957

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Barker, E. D., Walton, E., Cecil, C. A. M., Rowe, R., Jaffee, S. R., Maughan, B., O'Connor, T. G., Stringaris, A., Meehan, A. J., McArdle, W., Relton, C. L., & Gaunt, T. R. (2018). A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder. Child Development, 89(5), 1839-1855. https://doi.org/10.1111/cdev.12957

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title = "A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder",

abstract = "In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).",

keywords = "ALSPAC, Oppositional Defiant Disorder, Irritability, Headstrong, Attention Deficit Hyperactivity Disorder, DNA methylation",

author = "Barker, {Edward D} and Esther Walton and Cecil, {Charlotte A.M.} and Richard Rowe and Jaffee, {Sara R.} and Barbara Maughan and O'Connor, {Thomas G.} and Argyris Stringaris and Meehan, {Alan J.} and Wendy McArdle and Relton, {Caroline L.} and Gaunt, {Tom R.}",

year = "2018",

month = sep,

doi = "10.1111/cdev.12957",

language = "English",

volume = "89",

pages = "1839--1855",

journal = "Child Development",

issn = "0009-3920",

publisher = "Blackwell",

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Barker, ED, Walton, E, Cecil, CAM, Rowe, R, Jaffee, SR, Maughan, B, O'Connor, TG, Stringaris, A, Meehan, AJ, McArdle, W, Relton, CL & Gaunt, TR 2018, 'A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder', Child Development, vol. 89, no. 5, pp. 1839-1855. https://doi.org/10.1111/cdev.12957

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T1 - A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

AU - Barker, Edward D

AU - Walton, Esther

AU - Cecil, Charlotte A.M.

AU - Rowe, Richard

AU - Jaffee, Sara R.

AU - Maughan, Barbara

AU - O'Connor, Thomas G.

AU - Stringaris, Argyris

AU - Meehan, Alan J.

AU - McArdle, Wendy

AU - Relton, Caroline L.

AU - Gaunt, Tom R.

PY - 2018/9

Y1 - 2018/9

N2 - In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).

AB - In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).

KW - ALSPAC

KW - Oppositional Defiant Disorder

KW - Irritability

KW - Headstrong

KW - Attention Deficit Hyperactivity Disorder

KW - DNA methylation

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U2 - 10.1111/cdev.12957

DO - 10.1111/cdev.12957

M3 - Article (Academic Journal)

C2 - 28929496

AN - SCOPUS:85030032652

SN - 0009-3920

VL - 89

SP - 1839

EP - 1855

JO - Child Development

JF - Child Development

IS - 5

ER -

A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

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A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

Abstract

Keywords

Access to Document

Handle.net

Other files and links

Embargoed Document

Fingerprint

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IEU Theme 2

MRC UoB UNITE Unit - Programme 2

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Illumina Array

Cite this