A miniature confocal Raman probe for endoscopic use

JCC Day; R Bennett; B Smith; C Kendall; J Hutchings; G M Meaden; C Born; S Yu; N Stone

doi:10.1088/0031-9155/54/23/003

A miniature confocal Raman probe for endoscopic use

JCC Day, R Bennett, B Smith, C Kendall, J Hutchings, G M Meaden, C Born, S Yu, N Stone

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Abstract

Raman spectroscopy is a powerful tool for studying biochemical changes in the human body. We describe a miniature, confocal fibre optic probe intended to fit within the instrument channel of a standard medical endoscope. This probe has been optimized for the study of the carcinogenesis process of oesophageal malignancy. The optical design and fabrication of this probe is described including the anisotropic wet etching technique used to make silicon motherboards and jigs. Example spectra of PTFE reference samples are shown. Spectra with acquisition times as low as 2 s from resected oesophageal tissue are presented showing identifiable biochemical changes from various pathologies.

Translated title of the contribution	A miniature confocal Raman probe for endoscopic use
Original language	English
Pages (from-to)	7077 - 7087
Number of pages	11
Journal	Physics in Medicine and Biology
Volume	54
DOIs	https://doi.org/10.1088/0031-9155/54/23/003
Publication status	Published - Dec 2009

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Publisher: Institute of Physics

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http://iopscience.iop.org/0031-9155/54/23/003/

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title = "A miniature confocal Raman probe for endoscopic use",

abstract = "Raman spectroscopy is a powerful tool for studying biochemical changes in the human body. We describe a miniature, confocal fibre optic probe intended to fit within the instrument channel of a standard medical endoscope. This probe has been optimized for the study of the carcinogenesis process of oesophageal malignancy. The optical design and fabrication of this probe is described including the anisotropic wet etching technique used to make silicon motherboards and jigs. Example spectra of PTFE reference samples are shown. Spectra with acquisition times as low as 2 s from resected oesophageal tissue are presented showing identifiable biochemical changes from various pathologies.",

author = "JCC Day and R Bennett and B Smith and C Kendall and J Hutchings and Meaden, {G M} and C Born and S Yu and N Stone",

note = "Publisher: Institute of Physics",

year = "2009",

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doi = "10.1088/0031-9155/54/23/003",

language = "English",

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TY - JOUR

T1 - A miniature confocal Raman probe for endoscopic use

AU - Day, JCC

AU - Bennett, R

AU - Smith, B

AU - Kendall, C

AU - Hutchings, J

AU - Meaden, G M

AU - Born, C

AU - Yu, S

AU - Stone, N

N1 - Publisher: Institute of Physics

PY - 2009/12

Y1 - 2009/12

N2 - Raman spectroscopy is a powerful tool for studying biochemical changes in the human body. We describe a miniature, confocal fibre optic probe intended to fit within the instrument channel of a standard medical endoscope. This probe has been optimized for the study of the carcinogenesis process of oesophageal malignancy. The optical design and fabrication of this probe is described including the anisotropic wet etching technique used to make silicon motherboards and jigs. Example spectra of PTFE reference samples are shown. Spectra with acquisition times as low as 2 s from resected oesophageal tissue are presented showing identifiable biochemical changes from various pathologies.

AB - Raman spectroscopy is a powerful tool for studying biochemical changes in the human body. We describe a miniature, confocal fibre optic probe intended to fit within the instrument channel of a standard medical endoscope. This probe has been optimized for the study of the carcinogenesis process of oesophageal malignancy. The optical design and fabrication of this probe is described including the anisotropic wet etching technique used to make silicon motherboards and jigs. Example spectra of PTFE reference samples are shown. Spectra with acquisition times as low as 2 s from resected oesophageal tissue are presented showing identifiable biochemical changes from various pathologies.

U2 - 10.1088/0031-9155/54/23/003

DO - 10.1088/0031-9155/54/23/003

M3 - Article (Academic Journal)

C2 - 19904034

VL - 54

SP - 7077

EP - 7087

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

ER -

A miniature confocal Raman probe for endoscopic use

Abstract

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