A miniature confocal Raman probe for endoscopic use

JCC Day, R Bennett, B Smith, C Kendall, J Hutchings, G M Meaden, C Born, S Yu, N Stone

Research output: Contribution to journalArticle (Academic Journal)

72 Citations (Scopus)

Abstract

Raman spectroscopy is a powerful tool for studying biochemical changes in the human body. We describe a miniature, confocal fibre optic probe intended to fit within the instrument channel of a standard medical endoscope. This probe has been optimized for the study of the carcinogenesis process of oesophageal malignancy. The optical design and fabrication of this probe is described including the anisotropic wet etching technique used to make silicon motherboards and jigs. Example spectra of PTFE reference samples are shown. Spectra with acquisition times as low as 2 s from resected oesophageal tissue are presented showing identifiable biochemical changes from various pathologies.
Original languageEnglish
Pages (from-to)7077 - 7087
Number of pages11
JournalPhysics in Medicine and Biology
Volume54
DOIs
Publication statusPublished - Dec 2009

Bibliographical note

Publisher: Institute of Physics

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    Day, JCC., Bennett, R., Smith, B., Kendall, C., Hutchings, J., Meaden, G. M., Born, C., Yu, S., & Stone, N. (2009). A miniature confocal Raman probe for endoscopic use. Physics in Medicine and Biology, 54, 7077 - 7087. https://doi.org/10.1088/0031-9155/54/23/003