A Mixed-Method Study to Determine the Benefits of Periconceptional Folic Acid Supplementation and Effects of Folic Acid Deficiency in Mothers on Birth Outcomes

Gudlavalleti Venkata S Murthy; Sunanda Reddy Kolli; Sutapa B Neogi; Samiksha Singh; Komal Preet Allagh; Neena John; Srinivas N; Sudha Ramani; B R Shamanna; Pat Doyle; Sanjay Kinra; Andy Ness; Dinesh Raj Pallepogula; Hira B Pant; Smiksha Babbar; Raghunath Reddy; Rachna Singh

doi:10.2196/resprot.5722

A Mixed-Method Study to Determine the Benefits of Periconceptional Folic Acid Supplementation and Effects of Folic Acid Deficiency in Mothers on Birth Outcomes

Gudlavalleti Venkata S Murthy, Sunanda Reddy Kolli, Sutapa B Neogi, Samiksha Singh, Komal Preet Allagh, Neena John, Srinivas N, Sudha Ramani, B R Shamanna, Pat Doyle, Sanjay Kinra, Andy Ness, Dinesh Raj Pallepogula, Hira B Pant, Smiksha Babbar, Raghunath Reddy, Rachna Singh

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Abstract

BACKGROUND: Evidence from high income countries shows mothers who are supplemented with folic acid in their periconceptional period and early pregnancy have significantly reduced adverse outcomes like birth defects. However, in India there is a paucity of data on association of birth defects and folic acid supplementation. We identified a few important questions to be answered using separate scientific methods and then planned to triangulate the information.

OBJECTIVE: In this paper, we describe the protocol of our study that aims to determine the association of folic acid and pregnancy outcomes like neural tube defects (NTDs) and orofacial clefts (OFCs). We decided to fill the gaps in knowledge from India to determine public health consequences of folic acid deficiency and factors influencing dietary and periconceptional consumption of folic acid.

METHODS: The proposed study will be carried out in five stages and will examine the questions related to folic acid deficiency across selected locations in South and North India. The study will be carried out over a period of 4 years through the hierarchical evidence-based approach. At first a systematic review was conducted to pool the current birth prevalence of NTDs and orofacial clefts OFCs in India. To investigate the population prevalence, we plan to use the key informant method to determine prevalence of NTDs and OFCs. To determine the normal serum estimates of folic acid, iron, and vitamin B12 among Indian women (15-35 years), we will conduct a population-based, cross-sectional study. We will further strengthen the evidence of association between OFCs and folic acid by conducting a hospital-based, case-control study across three locations of India. Lastly, using qualitative methods we will understand community and health workers perspective on factors that decide the intake of folic acid supplements.

RESULTS: This study will provide evidence on the community prevalence of birth defects and prevalence folic acid and vitamin B12 deficiency in the community. The case-control study will help understand the association of folic acid deficiency with OFCs.

CONCLUSIONS: The results from this study are intended to strengthen the evidence base in childhood disability for planning and policy initiatives.

Original language	English
Article number	e129
Number of pages	11
Journal	JMIR Research Protocols
Volume	5
Issue number	2
Early online date	23 Jun 2016
DOIs	https://doi.org/10.2196/resprot.5722
Publication status	Published - Jun 2016

Keywords

folic acid
neural tube defects
orofacial clefts
periconceptional folic supplement
key informant method

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Murthy, G. V. S., Kolli, S. R., Neogi, S. B., Singh, S., Allagh, K. P., John, N., N, S., Ramani, S., Shamanna, B. R., Doyle, P., Kinra, S., Ness, A., Pallepogula, D. R., Pant, H. B., Babbar, S., Reddy, R., & Singh, R. (2016). A Mixed-Method Study to Determine the Benefits of Periconceptional Folic Acid Supplementation and Effects of Folic Acid Deficiency in Mothers on Birth Outcomes. JMIR Research Protocols, 5(2), Article e129. https://doi.org/10.2196/resprot.5722

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title = "A Mixed-Method Study to Determine the Benefits of Periconceptional Folic Acid Supplementation and Effects of Folic Acid Deficiency in Mothers on Birth Outcomes",

abstract = "BACKGROUND: Evidence from high income countries shows mothers who are supplemented with folic acid in their periconceptional period and early pregnancy have significantly reduced adverse outcomes like birth defects. However, in India there is a paucity of data on association of birth defects and folic acid supplementation. We identified a few important questions to be answered using separate scientific methods and then planned to triangulate the information.OBJECTIVE: In this paper, we describe the protocol of our study that aims to determine the association of folic acid and pregnancy outcomes like neural tube defects (NTDs) and orofacial clefts (OFCs). We decided to fill the gaps in knowledge from India to determine public health consequences of folic acid deficiency and factors influencing dietary and periconceptional consumption of folic acid.METHODS: The proposed study will be carried out in five stages and will examine the questions related to folic acid deficiency across selected locations in South and North India. The study will be carried out over a period of 4 years through the hierarchical evidence-based approach. At first a systematic review was conducted to pool the current birth prevalence of NTDs and orofacial clefts OFCs in India. To investigate the population prevalence, we plan to use the key informant method to determine prevalence of NTDs and OFCs. To determine the normal serum estimates of folic acid, iron, and vitamin B12 among Indian women (15-35 years), we will conduct a population-based, cross-sectional study. We will further strengthen the evidence of association between OFCs and folic acid by conducting a hospital-based, case-control study across three locations of India. Lastly, using qualitative methods we will understand community and health workers perspective on factors that decide the intake of folic acid supplements.RESULTS: This study will provide evidence on the community prevalence of birth defects and prevalence folic acid and vitamin B12 deficiency in the community. The case-control study will help understand the association of folic acid deficiency with OFCs.CONCLUSIONS: The results from this study are intended to strengthen the evidence base in childhood disability for planning and policy initiatives.",

keywords = "folic acid, neural tube defects, orofacial clefts, periconceptional folic supplement, key informant method",

author = "Murthy, {Gudlavalleti Venkata S} and Kolli, {Sunanda Reddy} and Neogi, {Sutapa B} and Samiksha Singh and Allagh, {Komal Preet} and Neena John and Srinivas N and Sudha Ramani and Shamanna, {B R} and Pat Doyle and Sanjay Kinra and Andy Ness and Pallepogula, {Dinesh Raj} and Pant, {Hira B} and Smiksha Babbar and Raghunath Reddy and Rachna Singh",

year = "2016",

month = jun,

doi = "10.2196/resprot.5722",

language = "English",

volume = "5",

journal = "JMIR Research Protocols",

issn = "1929-0748",

publisher = "JMIR Publications",

number = "2",

}

Murthy, GVS, Kolli, SR, Neogi, SB, Singh, S, Allagh, KP, John, N, N, S, Ramani, S, Shamanna, BR, Doyle, P, Kinra, S, Ness, A, Pallepogula, DR, Pant, HB, Babbar, S, Reddy, R & Singh, R 2016, 'A Mixed-Method Study to Determine the Benefits of Periconceptional Folic Acid Supplementation and Effects of Folic Acid Deficiency in Mothers on Birth Outcomes', JMIR Research Protocols, vol. 5, no. 2, e129. https://doi.org/10.2196/resprot.5722

A Mixed-Method Study to Determine the Benefits of Periconceptional Folic Acid Supplementation and Effects of Folic Acid Deficiency in Mothers on Birth Outcomes. / Murthy, Gudlavalleti Venkata S; Kolli, Sunanda Reddy; Neogi, Sutapa B et al.
In: JMIR Research Protocols, Vol. 5, No. 2, e129, 06.2016.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - A Mixed-Method Study to Determine the Benefits of Periconceptional Folic Acid Supplementation and Effects of Folic Acid Deficiency in Mothers on Birth Outcomes

AU - Murthy, Gudlavalleti Venkata S

AU - Kolli, Sunanda Reddy

AU - Neogi, Sutapa B

AU - Singh, Samiksha

AU - Allagh, Komal Preet

AU - John, Neena

AU - N, Srinivas

AU - Ramani, Sudha

AU - Shamanna, B R

AU - Doyle, Pat

AU - Kinra, Sanjay

AU - Ness, Andy

AU - Pallepogula, Dinesh Raj

AU - Pant, Hira B

AU - Babbar, Smiksha

AU - Reddy, Raghunath

AU - Singh, Rachna

PY - 2016/6

Y1 - 2016/6

N2 - BACKGROUND: Evidence from high income countries shows mothers who are supplemented with folic acid in their periconceptional period and early pregnancy have significantly reduced adverse outcomes like birth defects. However, in India there is a paucity of data on association of birth defects and folic acid supplementation. We identified a few important questions to be answered using separate scientific methods and then planned to triangulate the information.OBJECTIVE: In this paper, we describe the protocol of our study that aims to determine the association of folic acid and pregnancy outcomes like neural tube defects (NTDs) and orofacial clefts (OFCs). We decided to fill the gaps in knowledge from India to determine public health consequences of folic acid deficiency and factors influencing dietary and periconceptional consumption of folic acid.METHODS: The proposed study will be carried out in five stages and will examine the questions related to folic acid deficiency across selected locations in South and North India. The study will be carried out over a period of 4 years through the hierarchical evidence-based approach. At first a systematic review was conducted to pool the current birth prevalence of NTDs and orofacial clefts OFCs in India. To investigate the population prevalence, we plan to use the key informant method to determine prevalence of NTDs and OFCs. To determine the normal serum estimates of folic acid, iron, and vitamin B12 among Indian women (15-35 years), we will conduct a population-based, cross-sectional study. We will further strengthen the evidence of association between OFCs and folic acid by conducting a hospital-based, case-control study across three locations of India. Lastly, using qualitative methods we will understand community and health workers perspective on factors that decide the intake of folic acid supplements.RESULTS: This study will provide evidence on the community prevalence of birth defects and prevalence folic acid and vitamin B12 deficiency in the community. The case-control study will help understand the association of folic acid deficiency with OFCs.CONCLUSIONS: The results from this study are intended to strengthen the evidence base in childhood disability for planning and policy initiatives.

AB - BACKGROUND: Evidence from high income countries shows mothers who are supplemented with folic acid in their periconceptional period and early pregnancy have significantly reduced adverse outcomes like birth defects. However, in India there is a paucity of data on association of birth defects and folic acid supplementation. We identified a few important questions to be answered using separate scientific methods and then planned to triangulate the information.OBJECTIVE: In this paper, we describe the protocol of our study that aims to determine the association of folic acid and pregnancy outcomes like neural tube defects (NTDs) and orofacial clefts (OFCs). We decided to fill the gaps in knowledge from India to determine public health consequences of folic acid deficiency and factors influencing dietary and periconceptional consumption of folic acid.METHODS: The proposed study will be carried out in five stages and will examine the questions related to folic acid deficiency across selected locations in South and North India. The study will be carried out over a period of 4 years through the hierarchical evidence-based approach. At first a systematic review was conducted to pool the current birth prevalence of NTDs and orofacial clefts OFCs in India. To investigate the population prevalence, we plan to use the key informant method to determine prevalence of NTDs and OFCs. To determine the normal serum estimates of folic acid, iron, and vitamin B12 among Indian women (15-35 years), we will conduct a population-based, cross-sectional study. We will further strengthen the evidence of association between OFCs and folic acid by conducting a hospital-based, case-control study across three locations of India. Lastly, using qualitative methods we will understand community and health workers perspective on factors that decide the intake of folic acid supplements.RESULTS: This study will provide evidence on the community prevalence of birth defects and prevalence folic acid and vitamin B12 deficiency in the community. The case-control study will help understand the association of folic acid deficiency with OFCs.CONCLUSIONS: The results from this study are intended to strengthen the evidence base in childhood disability for planning and policy initiatives.

KW - folic acid

KW - neural tube defects

KW - orofacial clefts

KW - periconceptional folic supplement

KW - key informant method

U2 - 10.2196/resprot.5722

DO - 10.2196/resprot.5722

M3 - Article (Academic Journal)

C2 - 27339656

SN - 1929-0748

VL - 5

JO - JMIR Research Protocols

JF - JMIR Research Protocols

IS - 2

M1 - e129

ER -

A Mixed-Method Study to Determine the Benefits of Periconceptional Folic Acid Supplementation and Effects of Folic Acid Deficiency in Mothers on Birth Outcomes

Abstract

Keywords

UN SDGs

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