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A Modular Vaccine Platform Combining Self‐Assembled Peptide Cages and Immunogenic Peptides

Research output: Contribution to journalArticle

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A Modular Vaccine Platform Combining Self‐Assembled Peptide Cages and Immunogenic Peptides. / Morris, Caroline; Glennie, Sarah; Lam, Hon; Baum, Holly; Kandage, Dhinushi; Williams, Neil; Morgan, David; Woolfson, Dek; Davidson, Andrew.

In: Advanced Functional Materials, Vol. 29, No. 8, 1807357, 21.02.2019.

Research output: Contribution to journalArticle

Harvard

Morris, C, Glennie, S, Lam, H, Baum, H, Kandage, D, Williams, N, Morgan, D, Woolfson, D & Davidson, A 2019, 'A Modular Vaccine Platform Combining Self‐Assembled Peptide Cages and Immunogenic Peptides', Advanced Functional Materials, vol. 29, no. 8, 1807357. https://doi.org/10.1002/adfm.201807357

APA

Morris, C., Glennie, S., Lam, H., Baum, H., Kandage, D., Williams, N., ... Davidson, A. (2019). A Modular Vaccine Platform Combining Self‐Assembled Peptide Cages and Immunogenic Peptides. Advanced Functional Materials, 29(8), [1807357]. https://doi.org/10.1002/adfm.201807357

Vancouver

Morris C, Glennie S, Lam H, Baum H, Kandage D, Williams N et al. A Modular Vaccine Platform Combining Self‐Assembled Peptide Cages and Immunogenic Peptides. Advanced Functional Materials. 2019 Feb 21;29(8). 1807357. https://doi.org/10.1002/adfm.201807357

Author

Morris, Caroline ; Glennie, Sarah ; Lam, Hon ; Baum, Holly ; Kandage, Dhinushi ; Williams, Neil ; Morgan, David ; Woolfson, Dek ; Davidson, Andrew. / A Modular Vaccine Platform Combining Self‐Assembled Peptide Cages and Immunogenic Peptides. In: Advanced Functional Materials. 2019 ; Vol. 29, No. 8.

Bibtex

@article{45f7891f41904ca7b3d17c0f81be554a,
title = "A Modular Vaccine Platform Combining Self‐Assembled Peptide Cages and Immunogenic Peptides",
abstract = "Subunit vaccines use delivery platforms to present minimal antigenic compo- nents for immunization. The benefits of such systems include multivalency, self-adjuvanting properties, and more specific immune responses. Previously, the design, synthesis, and characterization of self-assembling peptide cages (SAGEs) have been reported. In these, de novo peptides are combined to make hubs that assemble into nanoparticles when mixed in aqueous solu- tion. Here it is shown that SAGEs are nontoxic particles with potential as accessible synthetic peptide scaffolds for the delivery of immunogenic com- ponents. To this end, SAGEs functionalized with the model antigenic peptides tetanus toxoid632-651 and ovalbumin323-339 drive antigen-specific responses both in vitro and in vivo, eliciting both CD4+ T cell and B cell responses. Additionally, SAGEs functionalized with the antigenic peptide hemag- glutinin518-526 from the influenza virus are also able to drive a CD8+ T cell response in vivo. This work demonstrates the potential of SAGEs to act asa modular scaffold for antigen delivery, capable of inducing and boosting specific and tailored immune responses.",
keywords = "coiled coils, peptide design, self-assembly, subunit vaccines, Synthetic biology",
author = "Caroline Morris and Sarah Glennie and Hon Lam and Holly Baum and Dhinushi Kandage and Neil Williams and David Morgan and Dek Woolfson and Andrew Davidson",
year = "2019",
month = "2",
day = "21",
doi = "10.1002/adfm.201807357",
language = "English",
volume = "29",
journal = "Advanced Functional Materials",
issn = "1616-301X",
publisher = "Wiley-VCH Verlag",
number = "8",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - A Modular Vaccine Platform Combining Self‐Assembled Peptide Cages and Immunogenic Peptides

AU - Morris, Caroline

AU - Glennie, Sarah

AU - Lam, Hon

AU - Baum, Holly

AU - Kandage, Dhinushi

AU - Williams, Neil

AU - Morgan, David

AU - Woolfson, Dek

AU - Davidson, Andrew

PY - 2019/2/21

Y1 - 2019/2/21

N2 - Subunit vaccines use delivery platforms to present minimal antigenic compo- nents for immunization. The benefits of such systems include multivalency, self-adjuvanting properties, and more specific immune responses. Previously, the design, synthesis, and characterization of self-assembling peptide cages (SAGEs) have been reported. In these, de novo peptides are combined to make hubs that assemble into nanoparticles when mixed in aqueous solu- tion. Here it is shown that SAGEs are nontoxic particles with potential as accessible synthetic peptide scaffolds for the delivery of immunogenic com- ponents. To this end, SAGEs functionalized with the model antigenic peptides tetanus toxoid632-651 and ovalbumin323-339 drive antigen-specific responses both in vitro and in vivo, eliciting both CD4+ T cell and B cell responses. Additionally, SAGEs functionalized with the antigenic peptide hemag- glutinin518-526 from the influenza virus are also able to drive a CD8+ T cell response in vivo. This work demonstrates the potential of SAGEs to act asa modular scaffold for antigen delivery, capable of inducing and boosting specific and tailored immune responses.

AB - Subunit vaccines use delivery platforms to present minimal antigenic compo- nents for immunization. The benefits of such systems include multivalency, self-adjuvanting properties, and more specific immune responses. Previously, the design, synthesis, and characterization of self-assembling peptide cages (SAGEs) have been reported. In these, de novo peptides are combined to make hubs that assemble into nanoparticles when mixed in aqueous solu- tion. Here it is shown that SAGEs are nontoxic particles with potential as accessible synthetic peptide scaffolds for the delivery of immunogenic com- ponents. To this end, SAGEs functionalized with the model antigenic peptides tetanus toxoid632-651 and ovalbumin323-339 drive antigen-specific responses both in vitro and in vivo, eliciting both CD4+ T cell and B cell responses. Additionally, SAGEs functionalized with the antigenic peptide hemag- glutinin518-526 from the influenza virus are also able to drive a CD8+ T cell response in vivo. This work demonstrates the potential of SAGEs to act asa modular scaffold for antigen delivery, capable of inducing and boosting specific and tailored immune responses.

KW - coiled coils

KW - peptide design

KW - self-assembly

KW - subunit vaccines

KW - Synthetic biology

UR - http://www.scopus.com/inward/record.url?scp=85059915773&partnerID=8YFLogxK

U2 - 10.1002/adfm.201807357

DO - 10.1002/adfm.201807357

M3 - Article

VL - 29

JO - Advanced Functional Materials

JF - Advanced Functional Materials

SN - 1616-301X

IS - 8

M1 - 1807357

ER -