Abstract
Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoperative morbidity and health service costs compared to a liberal threshold. Patients consent to take part in the study pre-operatively but are only randomised if their haemoglobin falls below 9g/dL during their post-operative hospital stay. The primary outcome is a binary composite outcome of any serious infectious or ischaemic event in the first three months after randomisation. Many challenges have been encountered in the set-up and running of the study.
Original language | English |
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Journal | Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis |
DOIs | |
Publication status | Published - 12 Mar 2014 |
Bibliographical note
Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.Research Groups and Themes
- BTC (Bristol Trials Centre)
- Centre for Surgical Research