A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: Study protocol

Rachel C M Brierley, Katie Pike, Alice Miles, Sarah Wordsworth, Elizabeth A Stokes, Andrew D Mumford, Alan Cohen, Gianni D Angelini, Gavin J Murphy, Chris A Rogers, Barnaby C Reeves

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)

Abstract

Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoperative morbidity and health service costs compared to a liberal threshold. Patients consent to take part in the study pre-operatively but are only randomised if their haemoglobin falls below 9g/dL during their post-operative hospital stay. The primary outcome is a binary composite outcome of any serious infectious or ischaemic event in the first three months after randomisation. Many challenges have been encountered in the set-up and running of the study.

Bibliographical note

Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Structured keywords

  • BTC (Bristol Trials Centre)
  • Centre for Surgical Research

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