A neural network underlying circadian entrainment and photoperiodic adjustment of sleep and activity in Drosophila

Matthias Schlichting, Pamela Menegazzi, Katharine Lelito, Zepeng Yao, Edgar Buhl, Elena Dalla Benetta, Andrew Bahle, Jennifer Denike, James Hodge, Charlotte Helfrich-Forster, Orie Shafer

Research output: Contribution to journalArticle (Academic Journal)peer-review

57 Citations (Scopus)
327 Downloads (Pure)

Abstract

A sensitivity of the circadian clock to light/dark cycles ensures that biological rhythms maintain optimal phase relationships with the external day. In animals the circadian clock neuron network (CCNN) driving sleep/activity rhythms receives light input from multiple photoreceptors, but how these photoreceptors modulate CCNN components is not well understood. Here we show that the Hofbauer-Buchner eyelets differentially modulate two classes of ventral lateral neurons (LNvs) within the Drosophila CCNN. The eyelets antagonize Cryptochrome (CRY)- and compound-eye-based photoreception in the large LNvs, while synergizing CRY-mediated photoreception in the small LNvs. Furthermore, we show that the large LNvs interact with subsets of “evening cells” to adjust the timing of the evening peak of activity in a day-length dependent manner. Our work identifies a peptidergic connection between the large LNvs and a group of evening cells that is critical for the seasonal adjustment of circadian rhythms.
Original languageEnglish
Pages (from-to)9084-9096
Number of pages13
JournalJournal of Neuroscience
Volume36
Issue number35
DOIs
Publication statusPublished - 31 Aug 2016

Keywords

  • Circadian
  • Entrainment
  • Photoreception
  • Pigment dispersing factor

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