A new avenue for treating neuronal diseases: Ceftriaxone, an old antibiotic demonstrating behavioral neuronal effects

Chun-Hwei Tai, Michele Bellesi, An-Chih Chen, Chih-Li Lin, Hsin-Hua Li, Pin-Jiun Lin, Wen-Chieh Liao, Ching-Sui Hung, Rainer K Schwarting, Ying-Jui Ho

Research output: Contribution to journalReview article (Academic Journal)peer-review

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Abstract

Several neurodegenerative disorders, namely Parkinson's disease dementia, dementia with Lewy bodies, and Alzheimer's disease, share common pathophysiological features, such as (1) cognitive deficits, (2) glutamatergic hyperactivity-related excitotoxicity, and (3) deposition of α-synuclein (α-syn) and β-amyloid (Aβ). Ceftriaxone (CEF) is a well-tested and safe drug that has been used as an antibiotic for several decades. Recent studies have demonstrated the following effects of CEF: (1) increasing glutamate transporter-1 expression and glutamate reuptake and suppressing excitotoxicity, (2) binding well with α-syn and inhibition of α-syn polymerization, (3) modulating expression of genes related to Aβ metabolism, and (4) enhancing neurogenesis and recovery of neuronal density. In addition, our data revealed that CEF ameliorates seizure and abnormal neuronal firing in the brain. These results suggest the potential of CEF in treating neuronal disorders. This paper addresses the effects and pharmacology of CEF.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalBehavioural Brain Research
Volume364
Early online date12 Feb 2019
DOIs
Publication statusPublished - 17 May 2019

Keywords

  • Neurodegenerative Disorders
  • Parkinson's disease dementia
  • dementia with lewy bodies
  • Alzheimer's disease
  • cetriaxone

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