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A new family of cell surface located purine transporters in Microsporidia and related fungal endoparasites

Research output: Contribution to journalArticle

Original languageEnglish
Article numbere47037
Number of pages23
JournaleLife
Volume8
DOIs
DateAccepted/In press - 23 Jul 2019
DatePublished (current) - 19 Aug 2019

Abstract

Plasma membrane-located transport proteins are key adaptations for obligate intracellular Microsporidia parasites, because they can use them to steal host metabolites the parasites need to grow and replicate. However, despite their importance, the functions and substrate specificities of most Microsporidia transporters are unknown. Here, we provide functional data for a family of transporters conserved in all microsporidian genomes and also in the genomes of related endoparasites. The universal retention among otherwise highly reduced genomes indicates an important role for these transporters for intracellular parasites. Using Trachipleistophora hominis, a Microsporidia isolated from an HIV/AIDS patient, as our experimental model, we show that the proteins are ATP and GTP transporters located on the surface of parasites during their intracellular growth and replication. Our work identifies a new route for the acquisition of essential energy and nucleotides for a major group of intracellular parasites that infect most animal species including humans.

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via eLife at https://doi.org/10.7554/eLife.47037 . Please refer to any applicable terms of use of the publisher.

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    Licence: CC BY

  • Full-text PDF Supplementary Material

    Rights statement: This is the final published version of the article (version of record). It first appeared online via eLife at https://doi.org/10.7554/eLife.47037 . Please refer to any applicable terms of use of the publisher.

    Final published version, 7 MB, PDF document

    Licence: CC BY

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