A new responder criterion (relative effect per patient (REPP) > 0.2) externally validated in a large total hip replacement multicenter cohort (EUROHIP).

J. Huber, J. Hüsler, P. Dieppe, K.P. Günther, K. Dreinhöfer, A. Judge

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

To validate a new method to identify responders (relative effect per patient (REPP) >0.2) using the OMERACT-OARSI criteria as gold standard in a large multicentre sample.The REPP ([score before - after treatment]/score before treatment) was calculated for 845 patients of a large multicenter European cohort study for THR. The patients with a REPP >0.2 were defined as responders. The responder rate was compared to the gold standard (OMERACT-OARSI criteria) using receiver operator characteristic (ROC) curve analysis for sensitivity, specificity and percentage of appropriately classified patients.With the criterion REPP>0.2 85.4% of the patients were classified as responders, applying the OARSI-OMERACT criteria 85.7%. The new method had 98.8% sensitivity, 94.2% specificity and 98.1% of the patients were correctly classified compared to the gold standard.The external validation showed a high sensitivity and also specificity of a new criterion to identify a responder compared to the gold standard method. It is simple and has no uncertainties due to a single classification criterion.
Original languageEnglish
Pages (from-to)480-483
Number of pages4
JournalOsteoarthritis and Cartilage
Volume24
Issue number3
Early online date27 Oct 2015
DOIs
Publication statusPublished - Mar 2016

Keywords

  • Humans
  • Osteoarthritis, Hip
  • Pain Measurement
  • Treatment Outcome
  • Arthroplasty, Replacement, Hip
  • Severity of Illness Index
  • Sensitivity and Specificity
  • Cohort Studies
  • Reproducibility of Results
  • Adult
  • Aged
  • Aged, 80 and over
  • Middle Aged
  • Female
  • Male

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