A new strategy for the stereoselective synthesis of 2,2′-bipyrrolidines

Mary J. Gresser, Paul A. Keller*, Steven M. Wales

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Abstract

A new strategy for the stereoselective synthesis of the 2,2′-bipyrrolidine scaffold is presented using a metathesis reaction followed by asymmetric dihydroxylation for the introduction of the stereogenic elements. This straightforward high-yielding process is suitable for application to the synthesis of additional heterocycles.

Original languageEnglish
Pages (from-to)4899-4902
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number34
DOIs
Publication statusPublished - 26 Aug 2009

Keywords

  • 2,2′-Bipyrrolidine
  • Asymmetric dihydroxylation
  • Chiral bisamine
  • Metathesis

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