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A novel framework to measure executive function in Down syndrome, with applications for early clinical diagnosis of dementia

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)354-373
JournalAmerican Journal on Intellectual and Developmental Disabilities
Volume124
Issue number4
DOIs
DateAccepted/In press - 11 Mar 2019
DatePublished (current) - 1 Jul 2019

Abstract

Executive function (EF) decline is a consistent early sign of Alzheimer’s disease (AD) among adults with Down syndrome (DS); baseline measures of EF for individuals with DS are vital to allow detection of meaningful decline. We developed a framework to extract measures of three core components of EF (memory updating, inhibitory, and temporal components) within one task. Increases in memory load, inhibitory load, and temporal demands led to significant increases in reaction times and significant decreases in accuracy among eighteen adults with DS and 18 typically developing matched individuals; thus the expected effects of all three manipulations were detected. Good test-retest reliability indicated that this framework has the potential to provide a simple, baseline EF measure for individuals with DS.

    Structured keywords

  • Memory
  • Physical and Mental Health

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  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via AAIDD at https://doi.org/10.1352/1944-7558-124.4.354 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 775 KB, PDF document

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