A novel hypothesis-generating approach for detecting phenotypic associations using epigenetic data

Flo Martin*, Kayleigh E Easey, Laura D Howe, Abigail Fraser, Debbie A Lawlor, Caroline L Relton, Gemma C Sharp

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Aim:
Hypotheses about what phenotypes to include in causal analyses, that in turn can have clinical and policy implications, can be guided by hypothesis-free approaches leveraging the epigenome, for example.

Materials & methods:
Minimally adjusted epigenome-wide association studies (EWAS) using ALSPAC data were performed for example conditions, dysmenorrhea and heavy menstrual bleeding (HMB). Differentially methylated CpGs were searched in the EWAS Catalog and associated traits identified. Traits were compared between those with and without the example conditions in ALSPAC.

Results:
Seven CpG sites were associated with dysmenorrhea and two with HMB. Smoking and adverse childhood experience score were associated with both conditions in the hypothesis-testing phase.

Conclusion:
Hypothesis-generating EWAS can help identify associations for future analyses.
Original languageEnglish
Pages (from-to)851-864
Number of pages14
JournalEpigenomics
Volume16
Issue number11-12
Early online date17 Jul 2024
DOIs
Publication statusPublished - 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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