A novel one-pot method for the preparation of pyrazoles by 1,3-dipolar cycloadditions of diazo compounds generated in situ

VK Aggarwal*, Javier Vicente-Fidalgo, RV Bonnert

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

257 Citations (Scopus)

Abstract

A convenient one-pot procedure for the preparation of pyrazoles by 1,3-dipolar cycloaddition of diazo compounds generated in situ has been developed. Diazo compounds derived from aldehydes were reacted with terminal alkynes to furnish regioselectively 3,5-disubstituted pyrazoles. Furthermore, the reaction of N-vinylimidazole and diazo compounds derived from aldehydes gave exclusively 3-substituted pyrazoles in a one-pot process.

Original languageEnglish
Pages (from-to)5381-5383
Number of pages3
JournalJournal of Organic Chemistry
Volume68
Issue number13
DOIs
Publication statusPublished - 27 Jun 2003

Keywords

  • ASYMMETRIC-SYNTHESIS
  • DIAZOALKANES

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