Abstract
Coiled coils are protein structure domains with two or more α-helices packed together via interlacing of side chains known as knob-into-hole packing. We analysed and classified a large set of coiled-coil structures using a combination of automated and manual methods. This led to a systematic classification that we termed a “periodic table of coiled coils,” which we have made available at http://coiledcoils.chm.bris.ac.uk/ccplus/search/periodic_table. In this table, coiled-coil assemblies are arranged in columns with increasing numbers of α-helices and in rows of increased complexity. The table provides a framework for understanding possibilities in and limits on coiled-coil structures and a basis for future prediction, engineering and design studies.
Translated title of the contribution | A periodic table of coiled-coil protein structures |
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Original language | English |
Pages (from-to) | 726 - 732 |
Number of pages | 7 |
Journal | Journal of Molecular Biology |
Volume | 385 (3) |
DOIs | |
Publication status | Published - Jan 2009 |