A pivotal role of GSK-3 in synaptic plasticity

CA Bradley, SAJ Peineau, C Taghibiglou, C Nicolas, D Whitcomb, ZA Bortolotto, B K Kaang, K Cho, Y T Wang, GL Collingridge

Research output: Contribution to journalArticle (Academic Journal)peer-review

150 Citations (Scopus)


Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.
Translated title of the contributionA pivotal role of GSK-3 in synaptic plasticity
Original languageEnglish
JournalFrontiers in Molecular Neuroscience
Publication statusPublished - Feb 2012


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