A pivotal role of GSK-3 in synaptic plasticity

CA Bradley; SAJ Peineau; C Taghibiglou; C Nicolas; D Whitcomb; ZA Bortolotto; B K Kaang; K Cho; Y T Wang; GL Collingridge

doi:10.3389/fnmol.2012.00013

A pivotal role of GSK-3 in synaptic plasticity

CA Bradley, SAJ Peineau, C Taghibiglou, C Nicolas, D Whitcomb, ZA Bortolotto, B K Kaang, K Cho, Y T Wang, GL Collingridge

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.

Translated title of the contribution	A pivotal role of GSK-3 in synaptic plasticity
Original language	English
Journal	Frontiers in Molecular Neuroscience
Volume	5
DOIs	https://doi.org/10.3389/fnmol.2012.00013
Publication status	Published - Feb 2012

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THE EFFECTS OF ACUTE STRESS ON GLUTAMATE RECEPTOR TRAFFICKING AND SYNAPTIC PLASTICITY IN THE HIPPOCAMPUS
Cho, K.
4/01/12 → 4/01/15
Project: Research
MECHANISMS OF NMDA RECEPTOR DEPENDANT LTP AND LTD IN THE HIPPOCAMPUS
Collingridge, G. L.
1/01/08 → 1/04/13
Project: Research

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title = "A pivotal role of GSK-3 in synaptic plasticity",

abstract = "Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.",

author = "CA Bradley and SAJ Peineau and C Taghibiglou and C Nicolas and D Whitcomb and ZA Bortolotto and Kaang, {B K} and K Cho and Wang, {Y T} and GL Collingridge",

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month = feb,

doi = "10.3389/fnmol.2012.00013",

language = "English",

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journal = "Frontiers in Molecular Neuroscience",

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T1 - A pivotal role of GSK-3 in synaptic plasticity

AU - Bradley, CA

AU - Peineau, SAJ

AU - Taghibiglou, C

AU - Nicolas, C

AU - Whitcomb, D

AU - Bortolotto, ZA

AU - Kaang, B K

AU - Cho, K

AU - Wang, Y T

AU - Collingridge, GL

PY - 2012/2

Y1 - 2012/2

N2 - Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.

AB - Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.

U2 - 10.3389/fnmol.2012.00013

DO - 10.3389/fnmol.2012.00013

M3 - Article (Academic Journal)

C2 - 22363262

SN - 1662-5099

VL - 5

JO - Frontiers in Molecular Neuroscience

JF - Frontiers in Molecular Neuroscience

ER -

A pivotal role of GSK-3 in synaptic plasticity

Abstract

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THE EFFECTS OF ACUTE STRESS ON GLUTAMATE RECEPTOR TRAFFICKING AND SYNAPTIC PLASTICITY IN THE HIPPOCAMPUS

MECHANISMS OF NMDA RECEPTOR DEPENDANT LTP AND LTD IN THE HIPPOCAMPUS

Cite this