A pivotal role of GSK-3 in synaptic plasticity

CA Bradley; SAJ Peineau; C Taghibiglou; C Nicolas; D Whitcomb; ZA Bortolotto; B K Kaang; K Cho; Y T Wang; GL Collingridge

doi:10.3389/fnmol.2012.00013

A pivotal role of GSK-3 in synaptic plasticity

CA Bradley, SAJ Peineau, C Taghibiglou, C Nicolas, D Whitcomb, ZA Bortolotto, B K Kaang, K Cho, Y T Wang, GL Collingridge

Research output: Contribution to journal › Article (Academic Journal) › peer-review

160 Citations (Scopus)

Abstract

Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.

Translated title of the contribution	A pivotal role of GSK-3 in synaptic plasticity
Original language	English
Journal	Frontiers in Molecular Neuroscience
Volume	5
DOIs	https://doi.org/10.3389/fnmol.2012.00013
Publication status	Published - Feb 2012

Access to Document

10.3389/fnmol.2012.00013

Handle.net

Persistent link

THE EFFECTS OF ACUTE STRESS ON GLUTAMATE RECEPTOR TRAFFICKING AND SYNAPTIC PLASTICITY IN THE HIPPOCAMPUS
Cho, K. (Principal Investigator)
4/01/12 → 4/01/15
Project: Research
MECHANISMS OF NMDA RECEPTOR DEPENDANT LTP AND LTD IN THE HIPPOCAMPUS
Collingridge, G. L. (Principal Investigator)
1/01/08 → 1/04/13
Project: Research

Cite this

@article{707030abe7694c7f98196a744f546550,

title = "A pivotal role of GSK-3 in synaptic plasticity",

abstract = "Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.",

author = "CA Bradley and SAJ Peineau and C Taghibiglou and C Nicolas and D Whitcomb and ZA Bortolotto and Kaang, \{B K\} and K Cho and Wang, \{Y T\} and GL Collingridge",

year = "2012",

month = feb,

doi = "10.3389/fnmol.2012.00013",

language = "English",

volume = "5",

journal = "Frontiers in Molecular Neuroscience",

issn = "1662-5099",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - A pivotal role of GSK-3 in synaptic plasticity

AU - Bradley, CA

AU - Peineau, SAJ

AU - Taghibiglou, C

AU - Nicolas, C

AU - Whitcomb, D

AU - Bortolotto, ZA

AU - Kaang, B K

AU - Cho, K

AU - Wang, Y T

AU - Collingridge, GL

PY - 2012/2

Y1 - 2012/2

N2 - Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.

AB - Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.

U2 - 10.3389/fnmol.2012.00013

DO - 10.3389/fnmol.2012.00013

M3 - Article (Academic Journal)

C2 - 22363262

SN - 1662-5099

VL - 5

JO - Frontiers in Molecular Neuroscience

JF - Frontiers in Molecular Neuroscience

ER -

A pivotal role of GSK-3 in synaptic plasticity

Abstract

Access to Document

Handle.net

Fingerprint

Projects

THE EFFECTS OF ACUTE STRESS ON GLUTAMATE RECEPTOR TRAFFICKING AND SYNAPTIC PLASTICITY IN THE HIPPOCAMPUS

MECHANISMS OF NMDA RECEPTOR DEPENDANT LTP AND LTD IN THE HIPPOCAMPUS

Cite this