A plasma-assisted bioextrusion system for tissue engineering

Fengyuan Liu, Weiguang Wang, Wajira Mirihanage, Sri Hinduja, Paulo Bartolo*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review


A challenge for tissue engineering is to produce synthetic scaffolds of adequate chemical, physical and biological cues effectively. This paper describes a plasma-assisted bio-extrusion system to produce functional-gradient scaffolds; it comprises pressure-assisted and screw-assisted extruders, and plasma jets. This paper also describes how the system conducts plasma surface modification during the polycaprolactone scaffold fabrication process. Water contact angle and in vitro biological tests confirm that the plasma modification alters the hydrophilicity properties of synthetic polymers and promotes proliferation of cells, leading to homogeneous cell colonization. The results suggest this system is promising for producing functional gradient scaffolds of biomaterials.
Original languageEnglish
Pages (from-to)229-232
JournalCIRP Annals - Manufacturing Technology
Issue number1
Publication statusPublished - 2018


  • Additive manufacturing
  • Biomedical
  • Tissue Engineering


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