Projects per year
Abstract
The observation of biological activity in solvent-free protein-polymer surfactant hybrids challenges the view of aqueous and nonaqueous solvents being unique promoters of protein dynamics linked to function. Here, we combine elastic incoherent neutron scattering and specific deuterium labeling to separately study protein and polymer motions in solvent-free hybrids. Myoglobin motions within the hybrid are found to closely resemble those of a hydrated protein, and motions of the polymer surfactant coating are similar to those of the hydration water, leading to the conclusion that the polymer surfactant coating plasticizes protein structures in a way similar to hydration water.
Original language | English |
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Pages (from-to) | 13168-13171 |
Number of pages | 4 |
Journal | Journal of the American Chemical Society |
Volume | 134 |
Issue number | 32 |
DOIs | |
Publication status | Published - 15 Aug 2012 |
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Dive into the research topics of 'A Polymer Surfactant Corona Dynamically Replaces Water in Solvent-Free Protein Liquids and Ensures Macromolecular Flexibility and Activity'. Together they form a unique fingerprint.Projects
- 1 Finished
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Chemical and biophysical studies of ionic protein fluids.
Perriman, A. W. (Principal Investigator)
1/05/10 → 1/05/13
Project: Research