A Polymer Surfactant Corona Dynamically Replaces Water in Solvent-Free Protein Liquids and Ensures Macromolecular Flexibility and Activity

Francois-Xavier Gallat, Alex P. S. Brogan, Yann Fichou, Nina McGrath, Martine Moulin, Michael Haertlein, Jerome Combet, Joachim Wuttke, Stephen Mann, Giuseppe Zaccai, Colin J. Jackson, Adam W. Perriman, Martin Weik

Research output: Contribution to journalArticle (Academic Journal)peer-review

40 Citations (Scopus)


The observation of biological activity in solvent-free protein-polymer surfactant hybrids challenges the view of aqueous and nonaqueous solvents being unique promoters of protein dynamics linked to function. Here, we combine elastic incoherent neutron scattering and specific deuterium labeling to separately study protein and polymer motions in solvent-free hybrids. Myoglobin motions within the hybrid are found to closely resemble those of a hydrated protein, and motions of the polymer surfactant coating are similar to those of the hydration water, leading to the conclusion that the polymer surfactant coating plasticizes protein structures in a way similar to hydration water.

Original languageEnglish
Pages (from-to)13168-13171
Number of pages4
JournalJournal of the American Chemical Society
Issue number32
Publication statusPublished - 15 Aug 2012

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